Extracellular matrix biology

edited by Richard O. Hynes, Kenneth M. Yamada

In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis. Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM.

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書名 Extracellular matrix biology
著作者等 Hynes, Richard O.
Hynes Richard O
Yamada Kenneth M (National Institute of Dental Research NIH)
Yamada Kenneth M.
書名別名 Extracellular matrix biology : a subject collection from Cold Spring Harbor Perspectives in Biology
シリーズ名 Cold spring harbor perspectives in biology
出版元 Cold Spring Harbor Laboratory Press
刊行年月 c2012
ページ数 viii, 397 p.
大きさ 26 cm
ISBN 9781936113385
NCID BB07856951
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言語 英語
出版国 アメリカ合衆国