NF-κB in health and disease

Michael Karin, editor

Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology-from immunity and inflammation to apoptosis, cell survival, growth, and proliferation

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  • Preface.- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms.- NF-kappaB/Rel proteins and the humoral immune responses of Drosophila melanogaster.- Specialized chromatin patterns in the control of inflammatory gene expression.- IKK regulation and human genetics.- Control of NF-kappaB activity by proteolysis.- NF-kappaB and Innate Immunity.- NF-kappaB and mucosal homeostasis.- IKK and NF-kappaB mediated functions in carcinogenesis.- Macrophages and NF-kappaB in Cancer.- NF-kappaB in liver cancer - the plot thickens.- NF-kappaB as a target for oncogenic viruses.- Inhibition of NF-kappaB signaling as a strategy in disease therapy.- Subject index

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書名 NF-κB in health and disease
著作者等 Karin, Michael
書名別名 NF-kB in health and disease
シリーズ名 Current topics in microbiology and immunology
出版元 Springer Berlin
刊行年月 c2011
ページ数 viii, 268 p.
大きさ 25 cm
ISBN 9783642160165
NCID BB06000354
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言語 英語
出版国 ドイツ