edited by Titia de Lange, Vicki Lundblad, Elizabeth Blackburn

An up-to-date survey of the current exciting state of telomere biology. Telomeres - specialized structures found at the ends of chromosomes - are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

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  • 1. A History of Telomere Biology 2. The Telomerase Ribonucleoprotein Particle 3. Telomerase Biochemistry and Biogenesis 4. Telomerase and Human Cancer 5. Modeling Cancer and Aging in the Telomerase-deficient Mouse 6. Telomerase Deficiency and Human Disease 7. Telomerase-independent Maintenance of Mammalian Telomeres 8. Telomerase-independent Telomere Maintenance in Yeast 9. Meiotic Telomeres 10. Telomere Position Effect: Silencing Near the End 11. The Structural Biology of Telomeres 12. Budding Yeast Telomeres 13. Mammalian Telomeres 14. Drosophila Telomeres 15. Ciliate Telomeres 16. Fission Yeast Telomeres 17. Plant Telomeres Appendix: A Personal Account of The Discovery of Telomerase Index

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書名 Telomeres
著作者等 Blackburn, Elizabeth H.
Blackburn Elizabeth
Lundblad Vicki
De Lange Titia
シリーズ名 Cold Spring Harbor monograph series
出版元 Cold Spring Harbor Laboratory Press
刊行年月 2006
版表示 2nd ed
ページ数 viii, 576 p.
大きさ 24 cm
ISBN 0879698101
NCID BA7465128X
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言語 英語
出版国 アメリカ合衆国