Dopamine in the CNS  1 ~ 2

contributors, E. Borrelli ... [et al.] ; editor, Gaetano Di Chiara

Dopamine was initially regarded as a mere precursor of noradrenaline, but has progressively gained its present status of a common target for major drug classes and a substrate for some basic functions and dysfunctions of the Central Nervous System. The scientific interest has shifted from typically motor areas of the striatum to traditionally limbic ones as the nucleus accumbens and its afferent areas, the prefrontal cortex, the hippocampal formation and the basolateral amygdala. This double volume provides a systematic account of the anatomy, physiology, neurochemistry, molecular biology and behavioural pharmacology of dopamine in the CNS. The second volume deals with functional and behavioural aspects as the electrophysiology of dopamine neurons and of dopamine actions, the interaction with other transmitters and its role in behaviour and in the action of centrally acting drugs.

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Dopamine was initially regarded as a mere precursor of noradrenaline, but has progressively gained its present status of a common target for major drug classes and a substrate for some basic functions and dysfunctions of the Central Nervous System. The scientific interest has shifted from typically motor areas of the striatum to traditionally limbic ones as the nucleus accumbens and its afferent areas, the prefrontal cortex, the hippocampal formation and the basolateral amygdala. This double volume provides a systematic account of the anatomy, physiology, neurochemistry, molecular biology and behavioural pharmacology of dopamine in the CNS. - The first volume deals with the history of dopamine, the anatomy of dopamine neurons, the biochemistry and molecular biology of dopamine uptake sites and of dopamine receptors.

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[目次]

  • 12. Electrophysiological Pharmacology of Mesencephalic Dopaminergic Neurons.- 13. Presynaptic Regulation of Dopamine Release.- 14. Dopamine - Acetylcholine Interactions.- 15. Dopamine - Glutamate Interactions.- 16. Dopamine - Adenosine Interactions.- 17. Dopamine - GABA Interactions.- 18. Dopamine - Its Role in Behaviour and Cognition in Experimental Animals and Humans.- 19. Molecular Knockout Approach to the Study of Brain Dopamine Function.- 20. Behavioural Pharmacology of Dopamine D2 and D3 Receptors: Use of the Knockout Mice Approach.- 21. Dopamine and Reward.- 22. Molecular and Cellular Events Regulating Dopamine Neuron Survival.- 23. Dopamine and Depression.- 24. Dopamine and Schizophrenia.- 25. Atypical Antipsychotics.- 26. Dopamine in the Sleep-Wake Cycle.

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[目次]

  • Introduction: Birth of Dopamine (by Arvid Carlsson) * 1. Brain Dopamine - a Historical Perspective * 2. Dopamine Neurons within the Organisation of the Forebrain * 3. Synaptology of Dopamine Neurons * 4. D1 Dopamine Receptors * 5. Function of the Dopamine D2 Receptor: A Knockout Animal Approach * 6. Dopamine D3 Receptor, Neuropsychiatric Disorders and their Treatments * 7. Dopamine D4 Receptors: Molecular Biology and Pharmacology * 8. Signal Transduction of Dopamine D1 Receptors * 9. The Dopamine Transporter: Molecular Biology, Pharmacology and Genetics * 10. Cellular Action of Dopamine * 11. Dopamine and Gene Expression.

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この本の情報

書名 Dopamine in the CNS
著作者等 Borrelli, E.
Di Chiara, Gaetano
Chiara Gaetano Di
シリーズ名 Handbook of experimental pharmacology
巻冊次 1
2
出版元 Springer-Verlag
刊行年月 c2002
ページ数 2 v. (xx, 344, xxiv, 514 p.)
大きさ 24 cm
ISBN 3540427201
3540427198
NCID BA57703117
※クリックでCiNii Booksを表示
言語 英語
出版国 ドイツ
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