Specificity, function, and development of NK cells : NK cells: the effector arm of innate immunity

edited by K. Kärre and M. Colonna

Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors.

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[目次]

  • NK receptors and coreceptors
  • activation of NK cells and effector functions
  • development of NK cells
  • role of NK cells in infections and tumours.

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この本の情報

書名 Specificity, function, and development of NK cells : NK cells: the effector arm of innate immunity
著作者等 Colonna, Marco
Kärre, Klas
Colonna M. (Basel Institute for Immunology Basel Switzerland)
Karre K. (Karolinska Institute Stockholm Sweden)
シリーズ名 Current topics in microbiology and immunology
出版元 Springer-Verlag
刊行年月 c1998
ページ数 viii, 248 p.
大きさ 25 cm
ISBN 3540639411
NCID BA35215801
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言語 英語
出版国 ドイツ
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