Hereditary diseases and blood transfusion : proceedings of the Nineteenth International Symposium on Blood Transfusion, Groningen, 1994

organized by the Red Cross Blood Bank, Groningen-Drenthe ; edited by C.Th. Smit Sibinga and P.C. Das, and E. Briët

The discovery of the structure and function of DNA and the cracking of the genetic code have led to rapid advances in gene therapy and screening and diagnosis on a molecular basis. While initial therapy has been for patients with single gene defects, there is increasing interest in acquired disease, using the approach to assess or treat cancer. Virtually all tissues are being studied for genetic modification, including bone marrow and blood cells. The 19th International Symposium on Blood Transfusion focused on hereditary disease and blood transfusion, demonstrating the relevance and importance of transfusion medicine. Gene therapy, whether for short-term effect or long-term support, will increase the safety, dignity and quality of life for a group of patients with diseases, abnormalities and handicaps that have hitherto only been supported and palliated. Audience: Essential reading for haematologists, Blood Bank specialists, pharmaceutical companies and health care professionals.

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[目次]

  • I. Blood coagulation: molecular biology of haemophilia, various types of von Willebrand disease and thrombophilia. II. Haemoglobin and red cells: globin gene regulation, molecular pathology of thalassaemia syndromes, options for bone marrow transplantation and gene therapy for haemoglobinopathies, molecular biology and genetic abnormalities in blood group serology. III. White cells and malignancies: role of the Blood Bank in human gene therapy trials and translocations in cancer, mechanism of oncogenic conversion and implications for therapy, role of topoisomerase IIalpha and beta isozymes in determining intrinsic and acquired drug resistance. IV. Gene technology, ethics and the future: ethics of genetic manipulation, impact of cell culture technology on transfusion medicine, strategies for making gene therapy work, the role of the Blood Bank in gene therapy.

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この本の情報

書名 Hereditary diseases and blood transfusion : proceedings of the Nineteenth International Symposium on Blood Transfusion, Groningen, 1994
著作者等 Briët, Ernest
Das, P. C.
International Symposium on Blood Transfusion
Smit Sibinga, C. Th
Stichting Rode Kruis Bloedbank Groningen/Drente
Briet E.
Sibinga C.Th.Smit
シリーズ名 Developments in hematology and immunology
出版元 Kluwer Academic
刊行年月 c1995
ページ数 xii, 256 p.
大きさ 25 cm
ISBN 0792336941
NCID BA27200773
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言語 英語
出版国 オランダ
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