Anticoagulants : physiologic, pathologic, and pharmacologic

editor, David Green

Anticoagulants provides authoritative reviews of proteins C and S, antithrombin III, and the recently described tissue factor pathway inhibitor. There are extensive discussions of pathologic anticoagulants, such as those found in patients with congenital clotting factor deficiencies or those that arise de novo in previously well individuals. Detailed clinical advice is presented for the management of patients with these inhibitors. A chapter on "lupus" anticoagulants provides a comprehensive review of the pathophysiology of these intriguing antibodies. Current guidelines are offered for the use of heparin, warfarin, and thrombolytic agents. The biochemistry, physiology, and clinical applications of the new, low molecular weight heparins are explored.

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  • Physiologic Inhibitors: Clinical and Physiological Manifestations of the Protein C Anticoagulant Pathway (C.T. Esmon). Protein S: Clinical and Laboratory Aspects (P.C. Comp). Antithrombin III (M. Manco-Johnson). Tissue Factor Pathway Inhibitor-A Regulator of Tissue Factor Induced Coagulation (M.S. Bajaj, A. Ameri, and S.P. Bajaj). Pathologic Inhibitors: Overview of Factor VIII Inhibitors (J.A. Penner). Immune Tolerance: Historical Perspective and Future Direction (D.M. DiMichele). Inhibitors of Factor VIII in Non-Hemophiliacs (D. Green). The Treatment of Acquired Hemophilia with Porcine Factor VIII Concentrate (C.M. Kessler). Use of Factor IX Complex Concentrates (Prothrombin Complex Concentrates) in Hemophiliacs with Inhibitor Antibodies to Factor VIII or Factor IX (J.M. Lusher). Pathologic Inhibitors (S. Glazer, U. Hedner, J.F. Falch). Lupus Anticoagulants (J.R. Chediak). Acquired von Willebrand's Disease (G.A. Soff). Acquired Inhibitors of Fibrin Stabilization: A Class of Hemorrhagic Disorders of Diverse Origins (L. Lorand). Pharmacologic Inhibitors: Heparin Therapy: Recent Advances in the Treatment of Venous and Arterial Thrombosis (G.F. Pineo, G.E. Raskob, and R.D. Hull). Warfarin Therapy (G.E. Raskob, P.C. Comp, G.F. Pineo, and R.D. Hull). Low Molecular Weight Heparins in the Management of Thrombotic Disorders (J. Fareed, D. Hoppensteadt, J.M. Walenga, W. Jeske, and A. Ahsan). Thrombolytic Therapy-Old and New (H.C. Kwaan).

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書名 Anticoagulants : physiologic, pathologic, and pharmacologic
著作者等 Green, David
出版元 CRC Press
刊行年月 c1994
ページ数 282 p.
大きさ 23 cm
ISBN 0849347629
NCID BA23930967
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言語 英語
出版国 アメリカ合衆国