Molecular biology of aging

edited by Avril D. Woodhead, Anthony D. Blackett, and Alexander Hollaender

Proceedings of a symposium held at the Brookhaven National Laboratory, Upton, New York, September 30-October 1, 1984

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  • Symposium Lecture - I.- Aging Research: Challenge of the Twenty-First Century.- Wear and Tear Hypotheses.- Introductory Remarks: Session II.- Antioxidants and Longevity of Mammalian Species.- Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory.- State of Knowledge on Action of Food Restriction and Aging.- The Endocrine Response to Dietary Restriction in the Rat.- Age Dependent Changes in Mitochondria.- Aging in Cellular Proteins.- Introductory Remarks: With Consideration of a T-Cell Model for Aging in Cellular Proteins.- Implications of 5?-Nucleotidase and its Inhibitor for Cellular Aging and Cancer.- The Effects of Dehydroepiandrosterone on the Rate of Development of Cancer and Autoimmune Processes in Laboratory Rodents.- The Alteration of Enzymes in Aging Animals.- Differential and Similar Responses Between Rodent and Human Cells to DNA-Damaging Agents: Possible Implications for Cellular Aging.- Symposium Lecture - II.- Living All Your Life.- Changes in DNA with Age - I.- Environmental and Genetic Factors that Influence Immunity and Longevity in Mice.- Cellular Senescence: Factors Modulating Cell Proliferation In Vitro.- Changes in Genetic Organisation and Expression in Aging Cells.- Changes in DNA with Age - II.- The Significance of DNA Methylation in Cellular Aging.- DNA Manipulating Genes and the Aging Brain.- In Vivo Studies on DNA Repair and Turnover with Age.- Hypersensitivity to DNA-Damaging Agents in Abiotrophies: A New Explanation for Degeneration of Neurons, Photoreceptors and Muscle in Alzheimer, Parkinson and Huntington Diseases, Retinitis Pigmentosa and Duchenne Muscular Dystrophy.- Reliability Theoretic Methods and Aging: Critical Elements, Hierarchies and Longevity-Interpreting Survival Curves.- Symposium Lecture - III.- The Odds on Normal Aging.- Diseases Featuring Altered Rates of Aging.- Introductory Remarks.- Progeria, A Model Disease for the Study of Accelerated Aging.- Amyloid, Immunopathology and Aging.- In Vitro Studies of Werner Syndrome Cells: Aberrant Growth and Chromosome behavior.- Molecular Basis of the Accumulation of Abnormal Proteins in Progeria and Aging Fibroblasts.- Future Directions in Aging Research.- Rapporteurs: R. W. Hart and A. Turturro.- L. Hayflick.- J. E. Seegmiller.- Participants.

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書名 Molecular biology of aging
著作者等 Blackett, Anthony D.
Hollaender, Alexander
Symposium on Molecular Basis of Aging
Woodhead, Avril D.
シリーズ名 Basic life sciences
出版元 Plenum Press
刊行年月 c1985
ページ数 xiv, 482 p.
大きさ 26 cm
ISBN 0306420848
NCID BA03484439
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言語 英語
出版国 アメリカ合衆国