New horizons in predictive toxicology : current status and application

edited by Alan G.E. Wilson

Modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of great importance. Such approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including the in silico, in vitro and in vivo approaches being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen our ability to predict the risks posed by industrial and pharmaceutical chemicals in humans. Extensive information on the use of current animal models used for various toxicities and target-mediated toxicities is included. Also discussed are the recently introduced regulatory initiatives.

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  • Introduction and overview
  • computational modeling approaches: in silico tools for toxicity prediction, development of an evaluation support system for estimating repeated dose toxicity of chemicals based on chemical structure, towards a common regulatory framework for computational toxicology: current status and future perspectives, information, informatics and modeling in predictive toxicology
  • in vitro approaches in predicting toxicity: cellular stress and in vitro predictive toxicology, in vitro genotoxicity, cardiac toxicity prediction: to simplify, or to integrate, that is the question, in vitro approaches for determining liver specific toxicity of new drug candidates, human-based in vitro experimental systems for the assessment of human-specific adverse drug effects: scientific concepts, current applications and promising approaches, models of organ injury,mitochondrial toxicity
  • in vivo approaches in predicting toxicity: nonclinical models for the evaluation of mechanisms of toxicity,in vivo genetic toxicology: application to cancer risk assessment, predicting hepatic toxicity in vivo, immunotoxicity testing,reproductive toxicity,toxicity biomarkers,renal toxicity, integrative approaches to toxicity prediction, metabolism-based toxicity prediction,impact of drug transporters in the pharmacological and adverse reactions of drugs,toxicokinetics, the role of computational systems biology models in toxicity testing in the 21st century: an example with predictive multi-scale models of the liver, animal models of idiosyncratic, drug-induced liver injury

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書名 New horizons in predictive toxicology : current status and application
著作者等 Benz, Robert Daniel
Boyer, Scott
Cronin, Mark T. D.
Hayashi, Makoto
Richard, Ann
Rotella, David P.
Thurston, David E.
Worth, Andrew
Yang, Chihae
Wilson Alan G. E.
シリーズ名 RSC drug discovery series
出版元 RSC Pub.
刊行年月 c2012
ページ数 xxix, 702 p.
大きさ 24 cm
ISBN 9781849730518
NCID BB11929582
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言語 英語
出版国 イギリス