Iron chelation therapy

edited by Chaim Hershko

Within the last few years, iron research has yielded exciting new insights into the understanding of normal iron homeostasis. Such development, and the evolution of improved strategies of Iron Chelating Therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant developments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload. This volume highlights the impact of long term Iron Celating Therapy using deferoxamine or the new, but controversial oral iron chelator deferiprone based on experience gained by multicenter trails, with special emphasis on survival, morbidity and drug toxicity; it reviews the development of the new and improved orally effective chelators suitable for clinical use in the near future and examines novel strategies of iron chelating treatment for the control of cell proliferation in malignant disease or malaria.

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[目次]

  • 1. Introduction
  • C. Hershko. 2. Pathophysiology of Iron Overload. 3. Chelation Therapy in Transfusional Siderosis. 4. Development of New Iron Chelators. 5. Novel Strategies in Iron Chelation Treatment. Index.

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この本の情報

書名 Iron chelation therapy
著作者等 Hershko, Chaim
シリーズ名 Advances in experimental medicine and biology
出版元 Kluwer Academic/Plenum Publishers
刊行年月 c2002
ページ数 viii, 277 p.
大きさ 26 cm
ISBN 0306467852
NCID BA62043811
※クリックでCiNii Booksを表示
言語 英語
出版国 アメリカ合衆国
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