Protecting group chemistry

Jeremy Robertson

"Protecting Group Chemistry" provides an overview of the general methods that are used to block the reactivity of - i.e. protect - specific functional groups thus allowing others, present within the same molecule, to be manipulated unambiguously. An introductory chapter outlines protecting group strategy, relevant aspects of functional group reactivity, temporary protection, and introduces the concept of protecting group devices as an aid to unifying the wide range of available methods. The rest of the book is divided on the basis of broad classes of the experimental conditions that lead to cleavage of each protecting group(acid/electrophile, base/nucleophile, oxidising or reducing agent). The treatment differs from traditional texts in that it places the emphasis on making a connection between the fundamental mechanisms of organic chemistry - ionisation, substitution, addition, elimination, oxidation and reduction, etc. - and how a particular protecting group can best be selected in a given situation.

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  • 1. Introduction
  • 2. Acid-labile protecting groups
  • 3. Nucleophile/base-labile protecting groups
  • 4. Redox deprotection

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書名 Protecting group chemistry
著作者等 Robertson, Jeremy
シリーズ名 Oxford science publications
Oxford chemistry primers
出版元 Oxford University Press
刊行年月 2000
ページ数 96 p.
大きさ 25 cm
ISBN 9780198502753
NCID BA48070279
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言語 英語
出版国 イギリス