Serotonin : from cell biology to pharmacology and therapeutics

edited by Rodolfo Paoletti ... [et al.]


  • Serotonin research: historical overview.- Molecular Mechanisms in Serotonin Mediated Response.- Molecular biology of the serotonin receptor family.- Molecular structure of the central 5-HT1A receptor.- Biochemical characterization of the cloned human 5-HT1A receptor expressed in mammalian cells.- Amplifying effects of 5-hydroxytryptamine on human platelets and signal transduction.- Role of phosphoinositide hydrolysis and protein kinase C activation in 5HT2 receptor function in smooth muscle.- Adenylate cyclase-linked 5-hydroxytryptamine receptors in the brain.- Characterization and purification of the neuronal 5-HT transporter.- Structure and functional expression of cloned human liver MAO A and B.- Physiology of Serotonergic System: - Vascular System.- Amplifying effect of serotonin in the control of vascular tone.- Amplification mechanisms in platelet activation.- The role of the endothelium in the cardiovascular response to serotonin.- Endothelium-dependent relaxations to serotonin: signal transduction and effects of diets.- 5-Hydroxytryptamine in cerebrovascular sympathetic nerves and its effect on brain vessels.- The 5-HT system of blood platelets: physiological variations and pathophysiology in essential hypertension.- Serotonergic regulation of renin and vasopressin secretion.- 5HT, platelets and experimental atherosclerosis.- Responses to serotonin in atherosclerotic and hypertensive blood vessels.- Does the serotonin antagonist ketanserin have vascular protective effects?.- Central Nervous System.- Serotonin and coexisting peptides in cat and lamprey spinal cord.- Is there an endogenous modulation of serotonin uptake?.- Serotonin receptors regulating transmitter release.- Galanin/5-HT receptor interactions. A new integrative mechanism in the control of 5-HT neurotransmission in the central nervous system.- Changing views on the role of serotonergic mechanisms in the control of the sleep-wakefulness cycle.- Serotonin transmission and food intake.- Serotonin in medial hypotholamic nuclei controls circadian patterns of macronutrient intake.- Serotonin receptor sub-types and the organisation of feeding behaviour: experimental models.- Tryptophan availability and serotonin synthesis.- Gastrointestinal System.- Effects of serotonin on gastric secretion in vivo.- Serotonin in intestinal function.- Messenger function of Serotonin in the enteric nervous system.- 5-Hydroxytryptamine and cholinergic function in the gastrointestinal tract.- Serotonergic Receptors: Biochemistry, Physiology and Pharmacology.- Functional/clinical significance of 5-hydroxytryptamine binding sites.- Selective agonists and antagonists at 5-hydroxytryptamine receptor subtypes.- Electrophysiology of brain serotonin receptors: subtype specificity for effector mechanisms.- 5-Hydroxytryptamine (5-HT) receptor subtypes in invertebrates.- 5-Hydroxytryptamine1A receptors: pharmacological and functional characterization.- Modulation of serotonin release in the central nervous system via presynaptic 5-HT autoreceptors.- Receptor binding correlates of functional terminal 5-HT autoreceptors.- Pharmacology, function and adaptive regulation of 5HT-1c receptors.- Classification of serotonergic receptors: an example of a novel 5-HT11 like binding site in the rabbit caudate nucleus.- Central and peripheral 5-HT2 receptors: role in physiological versus pathological conditions.- 5-HT3 receptors.- Brain 5-HT3 receptors.- Heart 5-HT receptors. A novel 5-HT receptor in human atrium.- Characterization of the contractile 5HT receptor in the rat stomach fundus.- Peripheral neural 5-HT receptors: subtypes in the enteric nervous system.- Antagonistic modulation of A K+ channel activity by serotonin and the peptide FMRFamide in aplysia sensory neurons: molecular aspects and functional implications.- Visualization of serotonin receptor binding and their messenger RNA's in the mammalian brain: an update.- Pharmacology of Serotonergic System.- Upregulation of pain transmission from deficient serotonergic analgesia in migraine.- Selective 5-hydroxytryptaminel-like receptor agonists and migraine.- Recent insights into the antihypertensive mechanism of action of ketanserin.- Ketanserin interactions with nifedipine and captopril: two italian cross over trials.- International study of ketanserin in Raynaud's phenomenon.- Serotonin and portal hypertension.- Effects of serotonin and ketanserin on the functional morphology of skin: organotypical cultures of adult human skin and embryonic chick skin as experimental models.- Use of antagonists to 5-HT2 receptors of serotonin by topical application in healing skin ulcers.- Ketanserin in wound healing and fibrosis: investigations into its mechanism of action.- Central Nervous System.- Serotonin uptake inhibitors.- Serotonergic re-uptake inhibition and depression: the effects of fluvoxamine on sleep in depressed patients.- Chronobiological studies of serotonin uptake complex: relevance to antidepressant action.- Lack of serotonergic influence on desipramine induced ss-adrenergic receptor down-regulation.- Serotonin in depression and anxiety.- Investigations of 5-HT neuroendocrine function in depression.- Electrophysiological investigation of the effects of antidepressant treatments on serotonin receptors.- Role of 5HT2 receptors in anxiety and depression.- Effectiveness of ritanserin on pain and depression in chronic headache disorders.- 5-HT1A receptor partial agonists as anxiolytics.- 5HT2 receptor antagonism and slow wave sleep in man.- Serotonin involvement in the action of antipsychotic drugs.- Serotonin control of anxiety.- Neuroendocrine System.- Endocrine changes and 5-hydroxytryptamine receptor subtypes.- Neuroendocrine effects of serotonin agonists in rhesus monkeys, healthy humans and patients with depression or anxiety disorders: effects of antidepressant treatment.- Hormonal responses to serotonergic drugs as a means to evaluate brain serotonergic function in humans.- Role of serotonin in the control of prolactin secretion: effect of antiserotoninergic drugs in normal subjects and in hyperprolactinaemic states.- Serotonin agonist induced corticosterone and prolactin secretion: role of 5-HT2 and 5-HT1A receptors.- Role of serotonin in regulation of the pituitary- adrenocortical axis in rats.- Short and Long Term Effects of Substituted Amphetamines.- Toxicity of amphetamine-related drugs and resulting behavioral changes.- Effect of chronic D-fenfluramine administration on rat brain serotonin levels and release.- Behavioral effects of 5, 7-DHT and MDMA treatment in rats.- Immunohistochemical and autoradiographic investigations of high-dose fenfluramine treatment on monoamine neurons in rat brain.- Long term actions of dexfenfluramine on food intake, body weight and brain serotonin in rodents.- Significance of fenfluramine neurotoxicity: a kinetic approach.- Effect of D-fenfluramine on appetite in lean and obese human subjects and on changes associated with PMS (pre-menstrual syndrome).- Criteria for assessing drug-induced biochemical alterations and degeneration of serotonergic neurons.

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書名 Serotonin : from cell biology to pharmacology and therapeutics
著作者等 International Symposium on "Serotonin : from Cell Biology to Pharmacology and Therapeutics"
Paoletti, Rodolfo
Brunello Nicoletta
Maggi Franco M. (Institute of Pharmacological Sciences University of Milan Italy)
Vanhoutte P.M.
出版元 Kluwer Academic Publishers;Sold and distributed in the U.S.A. and Canada by Kluwer Academic Publishers
刊行年月 c1990
ページ数 xviii, 668 p.
大きさ 25 cm
ISBN 0792305310
NCID BA11671657
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言語 英語
出版国 オランダ