Dynamics of proteins and nucleic acids

J. Andrew McCammon, Stephen C. Harvey

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.

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  • Preface
  • 1. Introduction
  • 2. Structure of proteins, nucleic acids, and their solvent surroundings
  • 3. Dynamics of proteins, nucleic acids, and their solvent surroundings
  • 4. Theoretical methods
  • 5. Short time dynamics
  • 6. Local structural transitions
  • 7. Global structural changes
  • 8. Dynamics of molecular associations
  • 9. Recent developments and future directions
  • Appendices
  • References
  • Index.

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書名 Dynamics of proteins and nucleic acids
著作者等 Harvey, Stephen C.
McCammon, J. Andrew
出版元 Cambridge University Press
刊行年月 1987
ページ数 xii, 234 p.
大きさ 24 cm
ISBN 0521356520
NCID BA01416303
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言語 英語
出版国 イギリス