The biology of cell reproduction  alk. paper

Renato Baserga

This synthesis of thirty-five years of intensive investigation comes at a particularly propitious moment. Since the Second World War, cell biology and molecular biology have worked separately in probing the central question of cancer research--how do cells divide?--biology focusing on cell behavior in isolation and as part of tissues and organs, molecular biology concentrating on individual biochemical steps, especially as controlled by genes. But now a new alliance is being forged in the continuing effort to conquer cancer. New discoveries point to the value of an interdisciplinary approach, and for the first time scientists from both camps are struggling to catch up on one another's literature. Baserga's work provides the unifying background for this cross-fertilization of ideas. It begins with the growth of cell populations and how cells interact with each other. The second section goes within the cell to consider the effect of drugs, the use of temperature-sensitive mutants of the cell cycle, and the use of cell fusion to understand how cells divide. The third section turns to the molecular genetics of cell proliferation, the growth factors, and the genes and gene products that regulate cell division. Drawing on more than five hundred classic and recent references, the book is comprehensive yet refreshingly readable. It will provide a congenial and sophisticated introduction for students as well as working scientists.

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  • PART I: BIOLOGY 1. The Cell Cycle Phases of the cell cycle Variability of the cell cycle 2. Nondividing Cells G0 cells Terminally differentiated cells 3. Populations of Cells Stem cells Transformed cells 4. Tissue Growth Growth in size Growth in number Doubling time Growth of tumors 5. Synchronization of Cells in the Cell Cycle Methods for synchronizing cells in culture Morphology of cells during the cell cycle PART II: CELL BIOLOGY 6. Temperature-Sensitive Mutants of the Cell Cycle Defining cell cycle mutants Conditional cell cycle mutants The execution point 7. Informational Content of Cells in Different Phases of the Cell Cycle Cell fusion Informational content of S phase cells Informational content of G0-G<small1 cells Premature chromosome condensation 8. Perturbation of the Cell Cycle by Drugs Actinomycin D Cycloheximide Other drugs Monoclonal antibodies 9. Growth in Size and Cell Proliferation Growth in size and cell DNA replication Growth in size and cell division The role of RNA polymerase II PART III: MOLECULAR BIOLOGY 10. The Environmental Signals Growth factors Inhibitory factors 11. Biochemical Events in the Cell Cycle Does the cell cycle exist? Controlling events and prerequisite events G1 and G0 S phase G2 and mitosis 12. Virally-Coded Proteins and Cell Proliferation SV4O and polyoma Adenovirus Other viruses Mechanisms of viral-induced cell DNA replication 13. Genetic Basis of Cell Proliferation Cdc genes in yeasts Retroviral oncogenes Cellular oncogenes Cdc genes in animal cells Some speculations References Index

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書名 The biology of cell reproduction
著作者等 Baserga, Renato
巻冊次 alk. paper
出版元 Harvard University Press
刊行年月 1985
ページ数 xi, 251 p.
大きさ 24 cm.
ISBN 0674074068
NCID BA00014199
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言語 英語
出版国 アメリカ合衆国