Pathobiology of cancer regimen-related toxicities

Stephen T. Sonis, Dorothy M. Keefe, editors

The contents of this book will be organized into three sections. The first section defines the scope, impact and behaviour of cancer regimen-related toxicities and frames the issue of balancing treatment success and physiological cost. In the second segment of the book, the most current thinking around the pathobiology of specific, common, and representative toxicities is presented by leading researchers and translational scientists. The final portion of the book discusses the common biological relationships between toxicities, bioinformatical approaches to analysing key and common pathways, and strategies for the development of effective interventions.

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  • Preface.-Epidemiology and outcomes of regimen-related toxicities.- The biological basis for differences in normal tissue response to radiation therapy and strategies to establish predictive assays for individual complication risk.- The bystander effect: Ionizing radiation-induced non-targeted effects: Evidence, mechanism and significance.- The role of genes on the metabolism of chemotherapeutic agents and their impact on toxicity.- Animal models of regimen-related toxicities.- Nausea and Vomiting.- Mucositis.- Dermatitis and Alopecia.- Fibrosis.- Myelosuppression.- Neuropathy.- Fatigue.- Xerostomia.- Osteonecrosis.- Conclusions and therapeutic opportunities.- Index.

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書名 Pathobiology of cancer regimen-related toxicities
著作者等 Sonis, Stephen T
Keefe Dorothy M.
出版元 Springer
刊行年月 c2013
ページ数 x, 292 p.
大きさ 25 cm
ISBN 9781461454373
NCID BB14816720
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言語 英語
出版国 アメリカ合衆国