Follow-up study of unilateral renal function after nephrectomy assessed by glomerular filtration rate per functional renal volume.

BACKGROUND: To evaluate the clinical usefulness of estimated glomerular filtration rate (eGFR) divided by functional renal volume (FRV) measured by three-dimensional image reconstruction (eGFR/FRV) for the prediction of functional outcomes after nephrectomy. METHODS: Eighty-three patients who underwent nephrectomy were enrolled. The FRV of each patient was measured before surgery. Preoperative medical information on proteinuria, blood pressure, blood glucose level, body mass index (BMI), hemoglobin level and serum cholesterol level were also obtained. We evaluated the relationships between eGFR/FRV and each of these parameters before surgery. We also assessed the potential relationship between eGFR/FRV and the 3-year postoperative eGFR. Stepwise multiple regression analyses were conducted to elucidate independent factors. RESULTS: The median FRV and eGFR were 310.15 cm3 and 79.0 ml/min/1.73 m² before surgery, respectively. The correlation between FRV and eGFR was statistically significant (r = 0.465, P < 0.001). The median eGFR/FRV was 0.24 ml/min/1.73 m²/cm³. Stepwise multiple regression analysis showed that the independent parameters (multiple correlation coefficient, r = 0.389, P = 0.031) associated with eGFR/FRV were proteinuria, BMI, age and hypertension. Proteinuria was statistically associated with eGFR/FRV, and the independent parameters (multiple correlation coefficient, r = 0.694, P < 0.001) associated with the 3-year postoperative eGFR were age, BMI and eGFR/FRV. The eGFR/FRV was statistically associated with the 3-year postoperative eGFR (r = 0.559, P < 0.001). CONCLUSION: The present results demonstrated that patients with proteinuria are expected to have a lower eGFR/FRV than those without proteinuria. The present study also supports the notion that eGFR/FRV is the primary determinant of the long-term functional outcome after nephrectomy. It should be taken into consideration that patients with a low eGFR/FRV may develop chronic kidney disease after nephrectomy.;博士(医学)・乙第1354号・平成27年3月16日;© 2014 Hosokawa et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.;開始ページ : 12:59;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/24641796

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書名 Follow-up study of unilateral renal function after nephrectomy assessed by glomerular filtration rate per functional renal volume.
著作者等 Anai, Satoshi
Fujimoto, Kiyohide
Hayashi, Yoshiki
Hirao, Yoshihiko
Hirayama, Akihide
Mibu, Hisakazu
Tanaka, Nobumichi
Torimoto, Kazumasa
Yoneda, Tatsuo
Yoshida, Katsunori
Hosokawa, Yukinari
書名別名 機能的腎体積あたりの腎機能の影響を考慮した腎摘除後の残存腎機能の検討
出版元 BioMed Central
刊行年月 2003-
ISSN 14777819
NCID AA12048269
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言語 英語
出版国 イギリス
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