Chondroitin sulfate prevents peritoneal fibrosis in mice by suppressing NF-κB activation

Japanese Society for Clinical Molecular Morphology

Long-term peritoneal dialysis causes peritoneal fibrosis, and previous reports suggest that inflammation plays a critical role in peritoneal fibrosis. Chondroitin sulfate (CS) suppresses the inflammatory response by preventing activation of nuclear factor (NF)-κB. We examined the effect of CS on the peritoneal fibrosis induced by chlorhexidine gluconate (CG) in mice. CS or water was administered daily. We divided mice into four groups: administered vehicle and water (control); administered vehicle and CS (CS); administered CG and water (CG); and administered CG and CS (CG+CS). Morphologic changes were assessed by Masson's trichrome staining. Inflammation- and fibrosis-associated factors were assessed by immunohistochemistry. Activation of NF-κB was examined by southwestern histochemistry. CS administration suppressed the progression of submesothelial thickening. The numbers of inflammation- and fibrosis-associated factors -positive cells were significantly decreased in the CG+CS group, compared to the CG group. Based on SWH, the CG+CS group contained significantly fewer NF-κB-activated cells than the CG group. Our results indicate that CS suppresses peritoneal fibrosis via suppression of NF-κB activation. These results suggest that CS has therapeutic potential for peritoneal fibrosis.;開始ページ : 144;終了ページ : 153;元資料の権利情報 : (C) The Japanese Society for Clinical Molecular Morphology 2016;元資料の権利情報 : The original publication is available at www.springerlink.com

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この本の情報

書名 Chondroitin sulfate prevents peritoneal fibrosis in mice by suppressing NF-κB activation
著作者等 日本臨床分子形態学会
阿部 伸一
書名別名 コンドロイチン硫酸はNF-κB活性化を抑制することでマウスの腹膜線維化を抑制する
出版元 Springer
刊行年月 2005-
ページ数 v.
大きさ 28 cm
ISSN 18601480
NCID AA12017629
※クリックでCiNii Booksを表示
全国書誌番号
01008537
※クリックで国立国会図書館サーチを表示
言語 英語
出版国 日本
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