In vivo observation of age-related structural changes of dermal collagen in human facial skin using collagen-sensitive second harmonic generation microscope equipped with 1250-nm mode-locked Cr:Forsterite laser

In vivo visualization of human skin aging is demonstrated using a Cr:Forsterite (Cr:F) laser-based, collagen-sensitive second harmonic generation (SHG) microscope. The deep penetration into human skin, as well as the specific sensitivity to collagen molecules, achieved by this microscope enables us to clearly visualize age-related structural changes of collagen fiber in the reticular dermis. Here we investigated intrinsic aging and/or photoaging in the male facial skin. Young subjects show dense distributions of thin collagen fibers, whereas elderly subjects show coarse distributions of thick collagen fibers. Furthermore, a comparison of SHG images between young and elderly subjects with and without a recent life history of excessive sun exposure show that a combination of photoaging with intrinsic aging significantly accelerates skin aging. We also perform image analysis based on two-dimensional Fourier transformation of the SHG images and extracted an aging parameter for human skin. The in vivo collagen-sensitive SHG microscope will be a powerful tool in fields such as cosmeceutical sciences and anti-aging dermatology.;博士(医学)・乙第1311号・平成25年5月29日;開始ページ : 31108-1;終了ページ : 31108-10;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/23212157

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書名 In vivo observation of age-related structural changes of dermal collagen in human facial skin using collagen-sensitive second harmonic generation microscope equipped with 1250-nm mode-locked Cr:Forsterite laser
著作者等 Society of Photo-optical Instrumentation Engineers
Araki Tsutomu
Fukushima Shu-ichiro
Hirao Tetsuji
International Biomedical Optics Society
Murota Hiroyuki
Ogura Yuki
Tanaka Ryosuke
Tanaka Yuji
Yamashita Toyonobu
Yonetsu Makoto
Yasui Takeshi
書名別名 1250nm帯モード同期クロム・フォルステライトレーザーを光源とした第2高調波発生光顕微鏡によるヒト顔皮膚の老化性真皮コラーゲン構造変化のその場観察
出版元 SPIE--the International Society for Optical Engineering
ページ数 v.
大きさ 29 cm
ISSN 10833668
NCID AA11237889
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言語 英語
出版国 アメリカ合衆国
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