Islet amyloid with macrophage migration correlates with augmented b-cell deficits in type 2 diabetic patients

Aims: Islet amyloid is a hallmark in type 2 diabetic subjects, but its implication in clinical features and development of islet pathology is still unclear.Methods: From 118 autopsy cases with type 2 diabetes, 26 cases with islet amyloid deposition (DA+) were selected. Twenty diabetic subjects without obvious amyloid deposition (DA ) matched for the age and diabetes duration and 20 non-diabetic subjects (ND) served for comparison. We examined the severity of amyloid deposition and its relationships with population of endocrine cells, expression of cell damage markers or macrophage infiltration. Correlation of clinical profile with islet pathology was also sought on the subset of the investigated patients.Results: b-Cell volume density was nearly 40% less in DA+ and 20% less in DA when compared to ND. Severity of amyloid deposition correlated with reduced volume densities of b-cell and a-cell, and increased body mass index (BMI), but not with duration of diabetes, age or HbA1c. Amyloid-rich islets contained an increased number of macrophages mixed with b-cells with oxidative stress-related DNA damage, characterized by gH2AX expression, and suppressed (pro)insulin mRNA expression.Conclusions: In Japanese type 2 diabetic patients, islet amyloid was more common with severe b-cell loss and high BMI, associated with macrophage infiltration.;開始ページ : 191;終了ページ : 201;PubMed番号 : info:pmid/25007035

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書名 Islet amyloid with macrophage migration correlates with augmented b-cell deficits in type 2 diabetic patients
著作者等 Inaba Wataru
International Society of Amyloidosis
Mizukami Hiroki
Tateishi Yoshinori
Tsuboi Kentaro
Yagihashi Soroku
Yoshida Taro
Kamata Kosuke
書名別名 2型糖尿病患者におけるアミロイド沈着は膵島内にマクロファージの浸潤を伴いβ細胞の減少と関連する
出版元 Informa Healthcare
ページ数 v.
大きさ 28 cm
ISSN 13506129
NCID AA11096426
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出版国 アメリカ合衆国
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