Possible peripheral mechanism for taste disorder in rats administered S-1.

[Japan Society of Clinical Oncology]

BACKGROUND: Taste disorders are frequently observed in cancer patients undergoing chemotherapy and are serious adverse events which impair the quality of life (QoL) of the cancer patient. Nevertheless, taste disorder mechanisms in cancer patients undergoing chemotherapy have not yet been fully elucidated. The aim of this study was to reveal taste disorder-related peripheral mechanisms using the two-bottle preference test (TBPT) and histological examination of tongues by hematoxylin-eosin staining and immunohistochemistry with protein-gene product 9.5.METHODS: In the TBPT, one bottle was filled with the 0.01 mM quinine hydrochloride (quinine), as a bitter compound, and the other was filled with water. Doses of 50 and 100 mg kg-1 day-1 S-1 (tegafur/gimeracil/oteracil potassium) are lethal to Wistar rats. Therefore, doses ranging from 2-20 mg kg-1 day-1 were administered to the rats for 3 weeks. The S-1 dose of 2 mg kg-1 day-1 corresponds to the clinical dose administered to cancer patients. The part of the tongue containing the circumvallate papillae was excised the following TBPT.RESULTS: The rate of increase in terms of the average preference rate for the quinine vs. all intake (quinine plus water) was significant from the initial S-1 period to the final one, compared with that in control rats, suggesting the possibility of a worsening sensation for the bitter taste. In S-1 rats, the area of taste nerve fibers were significantly decreased and the rate of degeneration of intra-tongue ganglionic nerve cells was significantly increased. These changes were significantly correlated with the rate of increase in average preference rate of the quinine.CONCLUSION: Neuropathy of the gustatory nerve at the periphery may be involved in taste disorders induced by an anticancer drug.;博士(医学)・乙1329号・平成26年3月17日;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/23733353



書名 Possible peripheral mechanism for taste disorder in rats administered S-1.
著作者等 日本癌治療学会
Kirita Tadaaki
Kuniyasu Hiroki
Kurihara Miyako
Obata Koji
Takaki Miyako
Aoki Kumiko
書名別名 S-1投与ラットにおける味覚障害の想定される末梢メカニズム
出版元 Springer-Verlag Tokyo / Japan Society for Cancer Therapy
刊行年月 c1996-
ページ数 v.
大きさ 28 cm
ISSN 13419625
NCID AA11086579
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言語 英語
出版国 日本

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