Noncardiovascular death, especially infection, is a significant cause of death in elderly patients with acutely decompensated heart failure.

BACKGROUND:Despite marked improvements in treatment strategies for heart failure (HF), the mortality rate of elderly patients with HF is still high. Detailed causes of death have not been fully understood.METHODS AND RESULTS:We studied 459 consecutive patients with acute decompensated HF (ADHF) emergently admitted to our hospital from 2007 to 2011. Patients were divided into 2 groups: <75 years old (younger group; n = 225) and ≥75 years old (elderly group; n = 234). All-cause death, cardiovascular death, and noncardiovascular death were assessed as adverse outcomes. Compared with the younger group, the elderly group was characterized by a higher proportion of women and hypertensive patients and higher left ventricular ejection fraction. During a mean follow-up of 20.7 months, a total of 174 patients (37.9%) died. All-cause death was significantly higher in the elderly group than in the younger group (46.6% vs 28.9%; P < .0001), and this difference was caused by an increase in noncardiovascular deaths (20.9% vs 9.3%; P < .001), especially deaths due to infection (10.7% vs 4.0%; P < .01). Cardiovascular deaths did not differ between the 2 groups.CONCLUSIONS:Noncardiovascular deaths, most of which were caused by infection, were frequent among elderly patients with ADHF.;博士(医学)・甲第629号・平成27年3月16日;Copyright © 2014 Elsevier Inc. All rights reserved.;開始ページ : 174;終了ページ : 180;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/24361802

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書名 Noncardiovascular death, especially infection, is a significant cause of death in elderly patients with acutely decompensated heart failure.
著作者等 Horii, Manabu
Kawakami, Rika
Kawata, Hiroyuki
Matsumoto, Takaki
Nishida, Taku
Okada, Sadanori
Okayama, Satoshi
Saito, Yoshihiko
Soeda, Tsunenari
Somekawa, Satoshi
Sugawara, Yu
Takeda, Yukiji
Uemura, Shiro
Watanabe, Makoto
Ueda, Tomoya
書名別名 高齢の非代償性心不全患者において、非心血管疾患、特に感染症は重要な死因である
出版元 Elsevier/Churchill Livingstone
刊行年月 c1994-
ページ数 v.
大きさ 28 cm
ISSN 10719164
NCID AA11054062
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言語 英語
出版国 アメリカ合衆国
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