REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms.

The aim of the present study was to evaluate the effects of the REG Iα and REG Iβ genes on lung cancer cell lines, and thereafter, the expression of REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP and REG IV) in lung cancer in relation to patient prognosis was evaluated. Lung adenocarcinoma (AD) and squamous cell carcinoma (SCC) cell lines expressing REG Iα or REG Iβ (HLC-1 REG Iα/Iβ and EBC-1 REG Iα/Iβ) were established, and cell number, cell invasive activity, and anchorage-independent cell growth were compared with these variables in the control cells. The expression levels of REG family genes were evaluated by real-time RT-PCR in surgically resected lung cancers, and disease-specific survival (DSS) curves were generated. The HLC-1 REG Iα/Iβ cell line showed significant increases in cell number and anchorage-independent cell growth compared with the control cells. EBC-1 REG Iα/Iβ cells showed significant increases in cell invasive activity and anchorage-independent cell growth as compared with the control cells. Except for the REG Iβ gene, expression of other REG family genes was observed in the surgically resected samples; however, DSS was significantly worse only in stage I patients who were positive for REG Iα expression than in patients who were negative for REG Iα expression. The effects of REG Iα on AD and SCC cells were different in the in vitro study, and a correlation between REG Iα expression and patient prognosis was noted in the in vivo study. Therefore, overexpression of REG Iα is a risk factor for poor prognosis caused by discrete mechanisms in AD and SCC patients.;博士(医学)・乙第1339号・平成26年5月28日;本文のリンク:http://dx.doi.org/10.3892/or.2013.2739;Copyright © Spandidos Publications 2014;開始ページ : 2625;終了ページ : 2631;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/24065141

「国立国会図書館デジタルコレクション(雑誌)」より

[目次]

  • 2015-04-01 再収集 / (03本文.pdf)

「国立国会図書館デジタルコレクション(雑誌)」より

この本の情報

書名 REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms.
著作者等 Ethnikon Hidryma Ereunōn
Dohi Yoshiko
Itaya-Hironaka Asako
Naito Hiroshi
Nakagawara Kan-Ichi
Takasawa Shin
Taniguchi Shigeki
Tojo Takashi
Yoshimura Mamiko
Kimura Michitaka
書名別名 肺癌におけるREG Iα遺伝子の発現は、腺癌、肩平上皮癌で異なったメカニズムにより、予後不良を示唆する。
出版元 National Hellenic Research Foundation / Spandidos
ページ数 v.
大きさ 29 cm
ISSN 1021335X
NCID AA11016405
※クリックでCiNii Booksを表示
言語 英語
出版国 ギリシャ
この本を: 
このエントリーをはてなブックマークに追加

Yahoo!ブックマークに登録
この記事をクリップ!
Clip to Evernote
このページを印刷

外部サイトで検索

この本と繋がる本を検索

ウィキペディアから連想