Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK- antibody- positive myasthenia gravis

Background and purpose: The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients are not clearly defined. Methods: The types of thymus histology, coexisting autoimmune diseases and associated Abs in 83 MuSK-Ab-positive patients nationwide were investigated and were compared with those in AChR-Ab-positive patients followed at our institute (n = 83). As for the autoantibodies associated with thymoma, titin Abs were measured. Results: Thymoma was not present in any of the MuSK-Ab-positive patients but presented in 21 patients (25.3%) amongst the AChR-Ab-positive patients. Titin Abs were absent in MuSK-Ab-positive patients but positive in 25 (30.1%) of the AChR-Ab-positive patients. Concomitant autoimmune diseases were present in eight MuSK-Ab-positive patients (9.6%) amongst whom Hashimoto's thyroiditis and rheumatoid arthritis predominated, whereas 22 AChR-Ab-positive patients (26.5%) had one or more concomitant autoimmune diseases of which Graves' disease predominated. Conclusions: Differences in frequency of thymoma and thymic hyperplasia, coexisting autoimmune diseases and autoantibody positivity between MuSK-Ab-positive and AChR-Ab-positive MG were indicated, suggesting that, in contrast with AChR-Ab-positive MG, thymus does not seem to be involved in the pathogenic mechanisms of MuSK-Ab-positive MG.;開始ページ : 1272;終了ページ : 1276;元資料の権利情報 : © 2013 EFNS.;元資料の権利情報 : This is the accepted version of the following article: European Journal of Neurology, 20(9), pp.1272-1276; 2013, which has been published in final form at http://dx.doi.org/10.1111/ene.12169

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書名 Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK- antibody- positive myasthenia gravis
著作者等 European Federation of Neurological Societies
中田 るか
書名別名 日本人MuSK抗体陽性重症筋無力症患者の胸腺組織と自己免疫疾患の合併
出版元 Blackwell
刊行年月 1995-
ページ数 v.
大きさ 28 cm
ISSN 13515101
NCID AA11015934
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言語 英語
出版国 イギリス
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