Lack of a surface layer in Tannerella forsythia mutants deficient in the type IX secretion system

Tannerella forsythia, a Gram-negative anaerobic bacterium, is an important pathogen in periodontal disease. This bacterium possesses genes encoding all known components of the type IX secretion system (T9SS). T. forsythia mutants deficient in genes orthologous to the T9SS-encoding genes porK, porT and sov were constructed. All porK, porT and sov single mutants lacked the surface layer (S-layer) and expressed less-glycosylated versions of the S-layer glycoproteins TfsA and TfsB. In addition, these mutants exhibited decreased haemagglutination and increased biofilm formation. Comparison of the proteins secreted by the porK and WT strains revealed that the secretion of several proteins containing C-terminal domain (CTD)-like sequences is dependent on the porK gene. These results indicate that the T9SS is functional in T. forsythia and contributes to the translocation of CTD proteins to the cell surface or into the extracellular milieu.;開始ページ : 2295;終了ページ : 2303;元資料の権利情報 : © 2014 Society for General Microbiology;元資料の権利情報 : This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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書名 Lack of a surface layer in Tannerella forsythia mutants deficient in the type IX secretion system
著作者等 Society for General Microbiology
成田 由香
書名別名 Tannerella forsythiaにおける9型分泌機構関連遺伝子変異株はsurface layerが欠失する
出版元 Society for General Microbiology
刊行年月 1994-
ページ数 v.
大きさ 28 cm
ISSN 13500872
NCID AA10958193
AA12024351
※クリックでCiNii Booksを表示
言語 英語
出版国 イギリス
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