Protective Effect of Nitric Oxide on Liver Circulation from Ischemia Reperfusion Injury

Introduction: The reduction of endogenous nitric oxide (NO) production during hepatic ischemia-reperfusion injury, generally via a reduction in endothelial NO synthase activity, leads to liver injury. We hypothesized that administration of an exogenous NO donor into the portal vein may ameliorate hepatic blood flow reduction after a period of ischemia.Material and Methods: A total of 90 min of ischemia (portal vein and hepatic artery) was applied in 15 anesthetized pigs, using the Pringle method under sevoflurane anesthesia. All animals were administered either saline (control group, n = 8) or sodium nitroprusside (SNP, n = 7) as exogenous NO donor drugs into the portal vein, 30 min before and after ischemia. The portal venous blood flow and hepatic artery blood flow were measured continuously using transonic flow probes attached to each vessel. Endogenous NO (NOx = NO2- + NO3-) production was measured every 10 min using a microdialysis probe placed in the left lobe of the liver.Results: In the SNP group, portal venous flow remained unchanged and hepatic artery flow significantly increased compared to baseline. Although the production of liver tissue NOx transiently decreased to 60% after ischemia, its level in the SNP group remained higher than the control saline group.Conclusion: Regional administration of SNP into the portal vein increases hepatic arterial flow during ischemia reperfusion periods without altering mean systemic arterial pressure. We speculate that administration of an exogenous NO donor may be effective in preventing liver injury via preservation of total hepatic blood flow.;開始ページ : 236;終了ページ : 244;元資料の権利情報 : © 2015 Taylor & Francis Group, LLC;元資料の権利情報 : This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Investigative Surgery on 20 Aug 2015, available online: http://www.tandfonline.com/10.3109/08941939.2015.1024357

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書名 Protective Effect of Nitric Oxide on Liver Circulation from Ischemia Reperfusion Injury
著作者等 Academy of Surgical Research
渡邊 利宏
書名別名 虚血再灌流障害における一酸化窒素の肝循環保護作用
出版元 Taylor & Francis Group, LLC
刊行年月 c1988-
ページ数 v.
大きさ 25 cm
ISSN 08941939
NCID AA10833234
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言語 英語
出版国 アメリカ合衆国
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