Histological and molecular characterization of the femoral attachment of the human ligamentum capitis femoris.

The ligamentum capitis femoris (LCF) has increased in clinical significance through the development of hip arthroscopy. The histological pathologies and molecular composition of the femoral attachment of the LCF and the degeneration caused by LCF disruption were investigated in the human hip joint. Twenty-four LCFs were retrieved at surgery for femoral neck fracture (age range: 63–87 years). In the "intact" (i.e., intact throughout its length, n = 12) group, the attachment consisted of rich fibrocartilage. Fibrocartilage cells were present in the midsubstance. In contrast, the construction of the attachment in the "disrupted" (i.e., ligament no longer attached to the femoral head, n = 12) group had disappeared. The attachment in the disrupted group was not labeled for type II collagen or aggrecan, while that in the intact group was labeled for types I, II and III collagen, chondroitin 4-sulfate, chondroitin 6-sulfate, aggrecan, and versican. The percentage of single-stranded DNA-positive chondrocytes was significantly higher in the disrupted group than in the intact group. We conclude that the femoral attachment of the LCF has a characteristic fibrocartilaginous structure that is likely to adjust to the mechanical load, and suggest that its degeneration is advanced by disruption and should be regarded as a clinical pathology.;博士(医学)・乙第1353号・平成27年3月16日;© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.;開始ページ : e245;終了ページ : e253;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/24355023

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書名 Histological and molecular characterization of the femoral attachment of the human ligamentum capitis femoris.
著作者等 Hayashi, Koji
Higashiyama, Ichiro
Kumai, Tsukasa
Matsuda, Takenori
Takakura, Yoshinoi
Tanaka, Yasuhito
Shinohara, Yasushi
書名別名 大腿骨頭靭帯の組織学的および分子学的特性に関する研究
出版元 Wiley
刊行年月 c1991-
ISSN 09057188
NCID AA10815119
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言語 英語
出版国 デンマーク
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