Peyer's Patches in the Terminal Ileum in Ulcerative Colitis: Magnifying Endoscopic Findings

Peyer's patches (PPs), a major component of the gut-associated lymphoid tissue, serve as important antigen entry sites in mucosal immunity. PPs may play a role in the extension of ulcerative colitis (UC) into the terminal ileum. We sought to clarify the magnified endoscopic findings of the PPs in the terminal ileum of UC patients. Eighteen UC patients underwent magnifying chromoendoscopy before initial treatment to evaluate the follicle-associated epithelium (FAE) on the PPs domes and the surrounding villi. In 8 UC patients, as in healthy controls, the PPs' domes were slightly elevated, covered with the regular FAE lining, and surrounded by dense and bulky villi; however, in 10 UC patients, the PPs' domes were irregular, and the surrounding villi were sparse and atrophic. These abnormal findings within the PPs were associated with minimal mucosal lesions but not with backwash ileitis; both electron microscopy and magnifying endoscopy confirmed that these lesions were reversible following remission with prednisolone-mesalazine therapy. Similar to Crohn's disease patients, UC patients commonly had abnormalities in the FAE on PPs' domes and the surrounding villi on magnifying endoscopy.;開始ページ : 111;終了ページ : 118;元資料の権利情報 : © 2010 The Editorial Secretariat of JCBN

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書名 Peyer's Patches in the Terminal Ileum in Ulcerative Colitis: Magnifying Endoscopic Findings
著作者等 応用生化学研究所
日本臨床栄養学会
日本過酸化脂質フリーラジカル学会
日本酸化ストレス学会
石居 公之
書名別名 潰瘍性大腸炎におけるパイエル板の拡大内視鏡観察の臨床的意義
出版元 日本酸化ストレス学会
刊行年月 c1986-
ページ数 v.
大きさ 26 cm
ISSN 09120009
NCID AA10710201
AA12091064
※クリックでCiNii Booksを表示
全国書誌番号
10035379
※クリックで国立国会図書館サーチを表示
言語 英語
出版国 日本
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