Microglia-derived neuregulin expression in psychiatric disorders.

Several studies have revealed that neuregulins (NRGs) are involved in brain function and psychiatric disorders. While NRGs have been regarded as neuron- or astrocyte-derived molecules, our research has revealed that microglia also express NRGs, levels of which are markedly increased in activated microglia. Previous studies have indicated that microglia are activated in the brains of individuals with autism spectrum disorder (ASD). Therefore, we investigated microglial NRG mRNA expression in multiple lines of mice considered models of ASD. Intriguingly, microglial NRG expression significantly increased in BTBR and socially-isolated mice, while maternal immune activation (MIA) mice exhibited identical NRG expression to controls. Furthermore, we observed a positive correlation between NRG expression in microglia and peripheral blood mononuclear cells (PBMCs) in mice, suggesting that NRG expression in human PBMCs may mirror microglia-derived NRG expression in the human brain. To translate these findings for application in clinical psychiatry, we measured levels of NRG1 splice-variant expression in clinically available PBMCs of patients with ASD. Levels of NRG1 type III expression in PBMCs were positively correlated with impairments in social interaction in children with ASD (as assessed using the Autistic Diagnostic Interview-Revised test: ADI-R). These findings suggest that immune cell-derived NRGs may be implicated in the pathobiology of psychiatric disorders such as ASD.;博士(医学)・乙第1404号・平成29年6月28日;Copyright © 2017 Elsevier Inc. All rights reserved.;開始ページ : 375;終了ページ : 385;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/28089559



書名 Microglia-derived neuregulin expression in psychiatric disorders.
著作者等 Fukami, Shin-ichi
Hashimoto, Ryota
Iwata, Keiko
Kanba, Shigenobu
Kato, Takahiro A.
Kimoto, Sohei
Kishimoto, Toshifumi
Makinodan, Manabu
Matsuzaki, Hideo
Mori, Norio
Ohgidani, Masahiro
Okumura, Kazuki
Owada, Yuji
Sugiyama, Toshiro
Tanaka, Tatsuhide
Toritsuka, Michihiro
Tsuchiya, Kenji
Tsujii, Masatsugu
Wanaka, Akio
Yamamuro, Kazuhiko
Yamashita, Yasunori
Yamauchi, Takahira
Yoshino, Hiroki
Ikawa, Daisuke
書名別名 精神疾患におけるマイクログリア由来ニューレグリン発現
出版元 Elsevier
刊行年月 [c1987]-
ISSN 08891591
NCID AA10708119
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言語 英語
出版国 アメリカ合衆国

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