Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Introduction: The effect of zoledronic acid, a potent and novel bisphosphonate, on tooth movement and orthodontically induced root resorption in osteoporotic animals systemically treated with zoledronic acid as similarly used in postmenopausal patients has not been elucidated. Therefore, this study was undertaken. Methods: Fifteen 10-week-old female Wistar rats were divided into 3 groups: ovariectomy, ovariectomy + zoledronic acid, and control. Only the ovariectomy and ovariectomy + zoledronic acid groups underwent ovariectomies. Two weeks after the ovariectomy, zoledronic acid was administered only to the ovariectomy + zoledronic acid group. Four weeks after the ovariectomy, 25-g nickel-titanium closed-coil springs were applied to observe tooth movement and orthodontically induced root resorption. Results: There were significant differences in the amounts of tooth movement and orthodontically induced root resorption between the ovariectomy and the control groups, and also between the ovariectomy and the ovariectomy + zoledronic acid groups. There was no statistically significant difference in tooth movement and orthodontically induced root resorption between the ovariectomy + zoledronic acid and the control groups. Zoledronic acid inhibited significantly more tooth movement and significantly reduced the severity of orthodontically induced root resorption in the ovariectomized rats. The ovariectomy + zoledronic acid group showed almost the same results as did the control group in both tooth movement and orthodontically induced root resorption. Conclusions: Zoledronic acid inhibits excessive orthodontic tooth movement and also reduces the risk of severe orthodontically induced root resorption in ovariectomized rats.;開始ページ : 563;終了ページ : 573;元資料の権利情報 : © 2012 American Association of Orthodontists. Published by Mosby, Inc.;元資料の権利情報 : NOTICE: this is the author's version of a work that was accepted for publication in American Journal of Orthodontics and Dentofacial Orthopedics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in American Journal of Orthodontics and Dentofacial Orthopedics, 141, 5(2012)

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書名 Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid
著作者等 American Association of Orthodontists
American Board of Orthodontics
Sirisoontorn Irin
書名別名 ゾレドロン酸を全身投与した卵巣摘出ラットにおける矯正的歯の移動と歯根吸収
出版元 Mosby, Inc
刊行年月 c1986-
ページ数 v.
大きさ 28 cm
ISSN 08895406
NCID AA10705697
※クリックでCiNii Booksを表示
言語 英語
出版国 アメリカ合衆国
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