Does the development of chronic kidney disease and acute kidney injury affect the prognosis after living donor liver transplantation?

Background and aims: Chronic kidney disease (CKD) and acute kidney injury (AKI) have been discussed as complications following living donor liver transplantation (LDLT). The aim of this study was to clarify the relationships among CKD, AKI, and the prognosis after LDLT. Methods: This study included 118 patients who underwent LDLT in our department. A low eGFR (<60 mL/min/1.73 m2) was regarded to indicate CKD. AKI 1 and AKI 2 were characterized by an increase in the serum creatinine level of 0.5 and 1.0 mg/dL, respectively, within one wk after LDLT. We investigated the risk factors for and the relevance of CKD and AKI on the prognosis. Results: AKI 1 was associated with sepsis and intra-operative bleeding (p = 0.0032, p = 0.001). AKI 2 was associated with sepsis and hepatitis C infection (p < 0.001, p = 0.027). A pre-operative eGFR of 60–89 and diabetes were the risk factors for the development of CKD in POY 2 (p = 0.018, p = 0.002). AKI 2, sepsis, and diabetes were the risk factors for the patient death within one yr after LDLT (p = 0.010, p = 0.002, p = 0.022). AKI 2 and sepsis were the risk factors for death within two yr after LDLT (p = 0.005, p = 0.018). Conclusions: Recognizing the risk factors and careful management for preventing both AKI and CKD may improve the prognosis of patients following LDLT.;開始ページ : 518;終了ページ : 527;元資料の権利情報 : © 2016 John Wiley & Sons A/S.;元資料の権利情報 : This is the accepted version of the following article: Clinical Transplantation, 30(5), pp.518-527; 2016, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/ctr.12715/full.

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書名 Does the development of chronic kidney disease and acute kidney injury affect the prognosis after living donor liver transplantation?
著作者等 井上 悠介
書名別名 慢性腎臓病、急性腎障害の生体肝移植後の予後に対する影響
出版元 John Wiley & Sons Ltd.
刊行年月 1987-
ページ数 v.
大きさ 28 cm
ISSN 09020063
NCID AA10694240
※クリックでCiNii Booksを表示
言語 英語
出版国 デンマーク
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