Primary cerebral and cerebellar astrocytes display differential sensitivity to extracellular sodium with significant effects on apoptosis.

Central pontine myelinolysis is one of the idiopathic or iatrogenic brain dysfunction, and the most common cause is excessively rapid correction of chronic hyponatraemia. While myelin disruption is the main pathology, as the diagnostic name indicates, a previous study has reported that astrocyte death precedes the destruction of the myelin sheath after the rapid correction of chronic low Na+ levels, and interestingly, certain brain regions (cerebral cortex, hippocampus, etc.) are specifically damaged but not cerebellum. Here, using primary astrocyte cultures derived from rat cerebral cortex and cerebellum, we examined how extracellular Na+ alterations affect astrocyte death and whether the response is different between the two populations of astrocytes. Twice the amount of extracellular [Na+] and voltage-gated Na+ channel opening induced substantial apoptosis in both populations of astrocytes, while, in contrast, one half [Na+] prevented apoptosis in cerebellar astrocytes, in which the Na+–Ca2+ exchanger, NCX2, was highly expressed but not in cerebral astrocytes. Strikingly, the rapid correction of chronic one half [Na+] exposure significantly increased apoptosis in cerebellar astrocytes but not in cerebral astrocytes. These results indicate that extracellular [Na+] affects astrocyte apoptosis, and the response to alterations in [Na+] is dependent on the brain region from which the astrocyte is derived.;博士(医学)・乙第1346号・平成26年12月3日;Copyright © 2014 John Wiley & Sons, Ltd.;開始ページ : 395;終了ページ : 400;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/24888443

「国立国会図書館デジタルコレクション(雑誌)」より

この本の情報

書名 Primary cerebral and cerebellar astrocytes display differential sensitivity to extracellular sodium with significant effects on apoptosis.
著作者等 Fukami, Shin-ichi
Ikawa, Daisuke
Kishimoto, Toshifumi
Makinodan, Manabu
Toritsuka, Michihiro
Yamashita, Yasunori
Takeda, Tomohiko
書名別名 大脳由来と小脳由来の初代培養アストロサイトは、アポトーシスに関連する細胞外ナトリウム感受性が異なる
出版元 Wiley-Blackwell
刊行年月 c1983-
ページ数 v.
大きさ 30 cm
ISSN 02636484
NCID AA1064014X
※クリックでCiNii Booksを表示
言語 英語
出版国 イギリス
この本を: 
このエントリーをはてなブックマークに追加

Yahoo!ブックマークに登録
この記事をクリップ!
Clip to Evernote
このページを印刷

外部サイトで検索

この本と繋がる本を検索

ウィキペディアから連想