Effect of labor on plasma concentrations and postpartum clearance of cell-free, pregnancy-associated, placenta-specific microRNAs

Objective: This study aimed to investigate the effect of labor on plasma concentrations of cell-free, pregnancy-associated, placenta-specific microRNAs (miRNAs) before and after delivery. Method: In the non-labor group (32 women), cesarean section (C/S) was performed before the beginning of labor. In the labor group (32 women), C/S was performed after the beginning of labor. Plasma concentrations of cell-free, pregnancy-associated, placenta-specific miRNAs (miR-515-3p, miR-517a, miR-517c, and miR-518b) were measured by real-time quantitative PCR. Each miRNA concentration was compared between the non-labor and labor groups. Results: Before C/S, plasma concentrations of cell-free, pregnancy-associated, placenta-specific miRNAs in the labor group were significantly higher than those in the non-labor group (P=0.001 for 515-3p, P=0.002 for 517a, P=0.001 for 517c, and P=0.003 for 518b). Twenty-four hours after delivery, plasma concentrations of cell-free, pregnancy-associated, placenta-specific miRNAs in the labor group were significantly higher than those in the non-labor group (P=0.002 for 515-3p, P=0.017 for 517a, P=0.043 for 517c, and P=0.009 for 518b). Conclusion: The presence of labor affects cell-free, pregnancy-associated, placenta-specific miRNA levels in maternal plasma. Labor also affects postpartum clearance of these miRNAs 24h after delivery.;開始ページ : 44;終了ページ : 50;元資料の権利情報 : © 2014 John Wiley & Sons, Ltd.;元資料の権利情報 : This is the peer reviewed version of the following article: Prenatal Diagnosis, 35(1), pp.44-50; 2015, which has been published in final form at http://dx.doi.org/10.1002/pd.4479 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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書名 Effect of labor on plasma concentrations and postpartum clearance of cell-free, pregnancy-associated, placenta-specific microRNAs
著作者等 森﨑 慎太郎
書名別名 母体血漿中への妊娠関連胎盤特異的microRNAの流入量および分娩後の消失速度と陣痛との関連について
出版元 John Wiley & Sons Ltd.
刊行年月 [1981]-
ページ数 v.
大きさ 25 cm
ISSN 01973851
NCID AA10624937
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言語 英語
出版国 イギリス
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