Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy

Recent developments in near-infrared spectroscopy (NIRS) have enabled the non-invasive elucidation of the neurobiological underpinnings of psychiatric disorders. Functional neuroimaging studies in human patients have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of obsessive-compulsive disorder (OCD). Here we used NIRS to investigate neurobiological function in 12 patients with OCD and 12 age- and sex-matched, healthy control subjects. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 sec, during performance of a Stroop color-word task, using 24-channel NIRS. Oxy-Hb changes in the prefrontal cortex of the OCD group were significantly smaller than those in the control group, especially in the left lateral prefrontal cortex. These results suggest that patients with OCD have reduced prefrontal hemodynamic responses as measured by NIRS.;博士(医学)・甲第599号・平成25年5月29日;開始ページ : 7;終了ページ : 13;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/23220093

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書名 Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy
著作者等 Elsevier Science Publishers
Iida Junzo
Kishimoto Naoko
Kishimoto Toshifumi
Ota Toyosaku
Okada koji
書名別名 近赤外線スペクトロスコピィで測定された成人強迫性障害における前頭前野の活動性の低下
出版元 Pergamon Press
ISSN 02785846
NCID AA1153785X
AA10532839
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言語 英語
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