Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease that is endemic in China, Korea and Japan. No effective vaccine or specific treatment for SFTS is currently available. Here, we used a mouse model to examine the effects of ribavirin, site-1 protease inhibitor PF-429242, steroids, and combination of minocycline and ciprofloxacin (MC) on SFTS infection. The antiserum from a patient who recovered from SFTS was also examined for its effect on mice. Administration of antiserum completely protected mice against lethal infection with SFTSV. It could also protect mice from showing clinical signs of the disease due to non-lethal infection. MC-treatment resulted in prolonged survival times during lethal infection. Although other agents had no significant protective effects, they did not provide detrimental effects that could lead to progression of the disease in mice. Our results suggest that antiserum treatment may be clinically useful for post-exposure prophylaxis against SFTSV infection.;開始ページ : 19;終了ページ : 27;元資料の権利情報 : © 2015 Elsevier Inc. All rights reserved.

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書名 Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection
著作者等 嶋田 聡
書名別名 重症熱性血小板減少症候群(SFTS)ウイルス感染マウスモデルを用いた抗血清療法の治療効果
出版元 Elsevier, Inc
刊行年月 c1955-
ページ数 v.
大きさ 23-28 cm
ISSN 00426822
NCID AA00884454
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言語 英語
出版国 アメリカ合衆国
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