Phosphorylation status of Fas-associated death domain protein is associated with biochemical recurrence after radical prostatectomy

OBJECTIVE: To assess whether the phosphorylated Fas-associated death domain protein (FADD) at 194 serine (p-FADD) is valuable as a marker of biochemical recurrence in hormone-naive patients who had undergone radical prostatectomy.MATERIALS AND METHODS: We used radical prostatectomy specimens from 106 patients. None of the patients had received neoadjuvant or adjuvant therapy. The percentage of positive p-FADD cells (nuclear staining) was immunohistochemically evaluated. The correlation between FADD phosphorylation and the clinicopathologic parameters was assessed. The correlation between the biochemical recurrence-free rate and the p-FADD expression level was analyzed using the Kaplan-Meier method.RESULTS: Overall, 39 patients developed biochemical recurrence. We investigated the expression of p-FADD in 106 patients with prostate cancer using immunohistochemistry. We compared our findings with the clinicopathologic parameters, including the follow-up data. Patients with a greater positive p-FADD rate had a significantly lower biochemical recurrence rate than those with a lower positive p-FADD rate (P < .001). A significant inverse correlation was found between the positive p-FADD rate and the Gleason score.CONCLUSION: A low expression of p-FADD could be a predictor of biochemical recurrence in hormone-naive patients who have undergone radical prostatectomy.;博士(医学)・乙第1313号・平成25年5月29日;開始ページ : 607;終了ページ : 610;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/23352370

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書名 Phosphorylation status of Fas-associated death domain protein is associated with biochemical recurrence after radical prostatectomy
著作者等 Anai, Satoshi
Fujimoto, Kiyohide
Hirao, Yoshihiko
Hirayama, Akihide
Konishi, Noboru
Matsumura, Yoshiaki
Miyake, Makito
Okajima, Eijiro
Shimada, Keiji
Tanaka, Nobumichi
Tomioka, Atsushi
Ikeda, Tomohiro
書名別名 FADDのリン酸化の状態と根治的前立腺全摘除術後の生化学的再発は関連する
出版元 Elsevier Science
ページ数 v.
大きさ 28 cm
ISSN 00904295
NCID AA0087924X
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言語 英語
出版国 アメリカ合衆国
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