Coagulation potential of immobilised factor VIII in flow-dependent fibrin generation on platelet surfaces.

Coagulation factor VIII (FVIII) plays an essential role in haemostasis. To date, physiologic activity of FVIII circulating in the bloodstream (S-FVIII) is evaluated by classic coagulation assays. However, the functional relevance of FVIII (-von Willebrand factor complex) immobilised on thrombogenic surfaces (I-FVIII) remains unclear. We used an in vitro perfusion chamber system to evaluate the function of I-FVIII in the process of mural thrombus formation under whole blood flow conditions. In perfusion of either control or synthetic haemophilic blood, the intra-thrombus fibrin generation on platelet surfaces significantly increased as a function of I-FVIII, independent of S-FVIII, under high shear rate conditions. This I-FVIII effect was unvarying regardless of anti-FVIII inhibitor levels in synthetic haemophilic blood. Thus, our results illustrate coagulation potentials of immobilised clotting factors, distinct from those in the bloodstream, under physiologic flow conditions and may give a clue for novel therapeutic approaches for haemophilic patients with anti-FVIII inhibitors.;博士(医学)・甲第602号・平成25年7月22日;The definitive version is available at " http://dx.doi.org/10.1160/TH13-02-0159 ";開始ページ : 316;終了ページ : 322;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/23636463

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書名 Coagulation potential of immobilised factor VIII in flow-dependent fibrin generation on platelet surfaces.
著作者等 Matsui, Hideto
Matsunari, Yasunori
Shima, Midori
Sugimoto, Mitsuhiko
Doi, Masaaki
出版元 Schattauer
ISSN 03406245
NCID AA00863137
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言語 英語
出版国 アメリカ合衆国
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