Adipose-derived regenerative cell therapy inhibits the progression of monocrotaline-induced pulmonary hypertension in rats

AimsFunctional and structural changes in pulmonary vasculature characterize pulmonary arterial hypertension (PAH) and the prognosis of advanced PAH remains poor despite progress in pharmacotherapy. Adipose-derived regenerative cells (ADRCs) promote cell regeneration at pathological sites and comprise a novel therapy for ailments of various organs. We investigated the effects of ADRC therapy in rat models of monocrotaline (MCT)-induced pulmonary hypertension (PH) and the underlying mechanisms.Main methodsRats were assigned to Control and MCT groups without and with (M/A) intravenous transfusion of seven million ADRCs on day 7. We echocardiographically evaluated pulmonary hypertension as pulmonary artery flow acceleration time (PAAT) and deceleration (PADc). Right ventricular (RV) systolic pressure was measured by catheterization on day 28 and then pathological changes in pulmonary vessels were assessed. We analyzed PAH-associated gene expression on day 14 using real-time RT-PCR.Key findingsEchocardiography and RV catheterization showed that ADRC therapy inhibited PH development (assessed as PAAT, PADc, and RV systolic pressure) at day 28 (MCT vs. M/A, P < 0.05). Pulmonary vascular remodeling was also inhibited (vessel wall thickness: MCT vs. M/A, P < 0.01). Messenger RNA levels of endothelin (ET) A and B receptors, ET-1 and transforming growth factor (TGF)-β increased in the lungs by MCT were suppressed by ADRCs (MCT vs. M/A, P < 0.05).SignificanceThe development of PH was inhibited by ADRCs through suppressing changes in the expression of genes associated with ET and TGF-β systems. We believe that ADRC therapy could serve as a novel strategy for treating PH.;開始ページ : 306;終了ページ : 312;元資料の権利情報 : © 2014 The Authors. Published by Elsevier Inc.;元資料の権利情報 : This is an openaccess article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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書名 Adipose-derived regenerative cell therapy inhibits the progression of monocrotaline-induced pulmonary hypertension in rats
著作者等 Elsevier Science Publishers
江口 正倫
書名別名 脂肪由来幹細胞(ADRCs)を用いた細胞移植療法の肺動脈性肺高血圧症モデルラットへの有効性の検討とそのメカニズムの解明
出版元 Elsevier, Inc
刊行年月 1973-
ページ数 v.
大きさ 24-27 cm
ISSN 00243205
NCID AA11536551
AA00717011
※クリックでCiNii Booksを表示
言語 英語
出版国 イギリス
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