IFN regulatory factor 4 (IRF4) in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major

the American Association of Immunologists

IRF4 is a transcription factor from the IRF factor family that plays pivotal roles in the differentiation and function of T and B lymphocytes. Although IRF4 is also expressed in dendritic cells (DCs) and macrophages, its roles in these cells in vivo are not clearly understood. In this study, conditional knockout mice that lack IRF4 in DCs or macrophages were generated and infected with Leishmania major. Mice lacking DC expression of IRF4 showed reduced footpad swelling compared with C57BL/6 mice, whereas those lacking IRF4 in macrophages did not. Mice with IRF4-deficient DCs also showed reduced parasite burden, and their CD4+ T cells produced higher levels of IFN-g in response to L. major Ag. In the draining lymph nodes, the proportion of activated CD4+ T cells in these mice was similar to that in the control, but the proportion of IFN-g-producing cells was increased, suggesting a Th1 bias in the immune response. Moreover, the numbers of migrating Langerhans cells and other migratory DCs in the draining lymph nodes were reduced both before and postinfection in mice with IRF4 defects in DCs, but higher levels of IL-12 were observed in IRF4-deficient DCs. These results imply that IRF4 expression in DCs inhibits their ability to produce IL-12 while promoting their migratory behavior, thus regulating CD4+ T cell responses against local infection with L. major.;開始ページ : 2271;終了ページ : 2279;元資料の権利情報 : (C) 2014 by The American Association of Immunologists, Inc.;元資料の権利情報 : The American Association of Immunologists, Inc., grant Dr. Akbari permission to reproduce the article in his thesis.

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書名 IFN regulatory factor 4 (IRF4) in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major
著作者等 American Association of Immunologists
Akbari Masoud
書名別名 リーシュマニア原虫感染において、樹状細胞に発現されるIRF4はIL-12産生を抑制しTh1免疫応答を制御する。
出版元 The American Association of Immunologists, Inc.
刊行年月 [1950]-
ページ数 v.
大きさ 28 cm
ISSN 00221767
NCID AA00699656
※クリックでCiNii Booksを表示
言語 英語
出版国 アメリカ合衆国
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