Autofluorescence imaging with a transparent hood for detection of colorectal neoplasms: a prospective, randomized trial.

BACKGROUND: Colonoscopy is one of the most reliable methods for detection of colorectal neoplasms, but conventional colonoscopy can miss some lesions.OBJECTIVE: To evaluate the efficacy of autofluorescence imaging (AFI) with a transparent hood (TH) for detection of colorectal neoplasms.DESIGN: A 2 × 2 factorial designed, prospective, randomized, controlled trial.SETTING: This study was conducted at the Osaka Medical Center for Cancer and Cardiovascular Diseases, a tertiary cancer center.PATIENTS: A total of 561 patients.INTERVENTIONS: Patients were allocated to 1 of 4 groups: (1) white light imaging (WLI) alone--colonoscopy using WLI without a TH; (2) WLI+TH--colonoscopy using WLI with a TH; (3) AFI alone--colonoscopy using AFI without a TH; and (4) AFI+TH--colonoscopy using AFI with a TH. Eight colonoscopists used each allocated method.MAIN OUTCOME MEASUREMENT: The difference in neoplasm detection rate (number of detected neoplasms per patient) between the WLI alone and AFI+TH groups.RESULTS: Neoplasm detection rate (95% confidence interval) in the AFI+TH group was significantly higher than in the WLI alone group (1.96 [1.50-2.43] vs 1.19 [0.93-1.44]; P = .023, Tukey-Kramer multiple comparison test). Relative detection ratios (95% confidence interval) for polypoid neoplasms based on Poisson regression model were significantly increased by mounting a TH (1.69 [1.34-2.12], P < .001), and relative detection ratios for flat neoplasms were significantly increased by AFI observation (1.83 [1.24-2.71], P = .002).LIMITATIONS: Open trial performed in single cancer referral center.CONCLUSION: AFI colonoscopy with a TH detected significantly more colorectal neoplasms than did conventional WLI colonoscopy without a TH.;博士(医学)・乙1327号・平成26年3月17日;開始ページ : 1006;終了ページ : 1013;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/21034901

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書名 Autofluorescence imaging with a transparent hood for detection of colorectal neoplasms: a prospective, randomized trial.
著作者等 American Society for Gastrointestinal Endoscopy
Chatani Rika
Hanafusa Masao
Hanaoka Noboru
Higashino Koji
Iishi Hiroyasu
Inoue Takuya
Ishihara Ryu
Kizu Takashi
Shimokawa Toshio
Tatsuta Masaharu
Uedo Noriya
Takeuchi Yoji
書名別名 大腸腫瘍性病変の拾い上げ診断における透明フードを併用した自家蛍光内視鏡の有用性:前向き無作為化比較試験
出版元 American Society for Gastrointestinal Endoscopy / Elsevier
ページ数 v.
大きさ 28 cm
ISSN 00165107
NCID AA00653961
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言語 英語
出版国 アメリカ合衆国
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