Individuals' half-lives for 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in blood: correlation with clinical manifestations and laboratory results in subjects with Yusho.

BACKGROUND: In 1968, many people developed dioxin poisoning (Yusho) in Japan. Ingestion of 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PeCDF) was considered to be the cause of this poisoning. Although some patients had high concentrations of 2,3,4,7,8-PeCDF in their blood, individuals' half-lives of 2,3,4,7,8-PeCDF were long.OBJECTIVES: To evaluate the relationship between clinical and laboratory parameters and the individual half-life of 2,3,4,7,8-PeCDF in blood.METHODS: Clinical and laboratory data were collected during annual check-ups from 2001 to 2008. We enrolled 71 patients, who were measured more than 3 times, and who had 2,3,4,7,8-PeCDF concentrations in blood >50pgg(-1) lipid. The half-life of 2,3,4,7,8-PeCDF for each patient was estimated using linear regression. Moreover, relationships between clinical and laboratory parameters and individual half-life were investigated by linear regression.RESULTS: A shortened individual half-life for 2,3,4,7,8-PeCDF was significantly correlated with an increased red blood cell count, increased viscous secretions from the meibomian glands, existing black comedones, and severe cedar pollen allergy.CONCLUSIONS: Symptoms that accelerate excretion of lipids from the body, such as viscous secretions from the meibomian glands, may lead to a shorter half-life of 2,3,4,7,8-PeCDF. Red blood cells are related to the half-life of 2,3,4,7,8-PeCDF. However, further studies are required to investigate the excretory mechanism of 2,3,4,7,8-PeCDF.;博士(医学)・乙1325号・平成26年3月17日;開始ページ : 772;終了ページ : 777;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/23651555

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書名 Individuals' half-lives for 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in blood: correlation with clinical manifestations and laboratory results in subjects with Yusho.
著作者等 Elsevier Science Publishers
Akahane Manabu
Furue Masutaka
Imamura Tomoaki
Kajiwara Jumboku
Kanagawa Yoshiyuki
Todaka Takashi
Uchi Hiroshi
Yasukawa Fumiko
Matsumoto Shinya
書名別名 血中の2,3,4,7,8-五塩化ダイベンゾフラン(PeCDF)の個人の半減期:油症患者における臨床症状並びに検診結果との関係
出版元 Elsevier Science Ltd
刊行年月 1972-
ISSN 00456535
NCID AA00603442
AA11523866
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言語 英語
出版国 イギリス
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