Upregulation of thrombospondin-1(TSP-1) expression in synovial tissues and plasma of rheumatoid arthritis (RA): Role of transforming growth factor-β1 toward fibroblast-like synovial cells

Objective: To investigate the role of thrombospondin 1 (TSP-1) in RA. Methods: Expression of TSP-1 in synovial tissues was determined by immunohistochemistry. Expression of TSP-1 in rheumatoid fibroblast-like synovial cells (FLS) was investigated by quantitative real-time PCR and ELISA. Correlations among the plasma TSP-1 and other variables in patients with RA were examined. Results: Expression of TSP-1 was increased in rheumatoid synovial tissues. Transforming growth factor-β1 (TGF-β1) clearly increased TSP-1 expression in FLS on both mRNA and protein levels. Changes in plasma TSP-1 were associated with those in 28-joint Disease Activity Score-erythrocyte sedimentation rate and plasma TGF-β1. Conclusion: TSP-1 might be critically involved in the disease process of RA through the TGF-β1/TSP-1 axis.;開始ページ : 943;終了ページ : 947;元資料の権利情報 : (C) 2015 The Journal of Rheumatology Publishing Company Limited.;元資料の権利情報 : This is a pre-copy-editing, author-produced PDF of an article accepted for publication in The Journal of Rheumatology following peer review. The definitive publisher-authenticated version: The Journal of Rheumatology, 42(6), pp.943-947; 2015 is available online at: http://dx.doi.org/10.3899/jrheum.141292.

「国立国会図書館デジタルコレクション(雑誌)」より

[目次]

  • 2016-07-07 再収集 / (ISYK768_Suzuki.pdf)

「国立国会図書館デジタルコレクション(雑誌)」より

この本の情報

書名 Upregulation of thrombospondin-1(TSP-1) expression in synovial tissues and plasma of rheumatoid arthritis (RA): Role of transforming growth factor-β1 toward fibroblast-like synovial cells
著作者等 鈴木 貴久
書名別名 Thrombospondin-1は関節リウマチにおいて滑膜組織及び血漿レベルで過剰発現しており、 滑膜線維芽細胞ではtransforming growth factor-β1により誘導される
出版元 The Journal of Rheumatology Publishing Company Limited
ページ数 v.
大きさ 26-28 cm
ISSN 0315162X
NCID AA00259948
AA00706194
※クリックでCiNii Booksを表示
言語 英語
出版国 カナダ
この本を: 
このエントリーをはてなブックマークに追加

Yahoo!ブックマークに登録
この記事をクリップ!
Clip to Evernote
このページを印刷

外部サイトで検索

この本と繋がる本を検索

ウィキペディアから連想