Clinical and immunologic features of recurrent herpes zoster (HZ).

BACKGROUND: Recurrent herpes zoster (HZ) is thought to be rare, but there have been few large-scale studies of recurrent HZ. OBJECTIVE: We conducted a large-scale prospective cohort study to characterize recurrent HZ. METHODS: We examined 12,522 participants aged 50 years or older in Shozu County and followed them up for 3 years. We compared the incidence of HZ and postherpetic neuralgia, severity of skin lesions and acute pain, cell-mediated immunity, and varicella-zoster virus-specific antibody titer between primary and recurrent HZ. RESULTS: A total of 401 participants developed HZ: 341 with primary HZ and 60 with recurrent HZ. Skin lesions and acute pain were significantly milder and the incidence of postherpetic neuralgia was lower in patients aged 50 to 79 years with recurrent HZ than in those with primary HZ. Varicella-zoster virus skin test induced a stronger reaction in patients aged 50 to 79 years with recurrent HZ than in those with primary HZ. LIMITATIONS: Information on previous HZ episodes was self-reported by participants, so it could not be confirmed that they actually had a history of HZ. CONCLUSION: Recurrent HZ was associated with milder clinical symptoms than primary HZ, probably because of stronger varicella-zoster virus-specific cell-mediated immunity in the patients with recurrence.;博士(医学)・甲第674号・平成29年9月27日;Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.;開始ページ : 950;終了ページ : 956;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/27473453

「国立国会図書館デジタルコレクション(雑誌)」より

この本の情報

書名 Clinical and immunologic features of recurrent herpes zoster (HZ).
著作者等 American Academy of Dermatology
Asada Hideo
Iso Hiroyasu
Miyagawa Fumi
Mori Yasuko
Okazaki Aiko
Okuno Yoshinobu
Shozu Herpes Zoster Study Group
Yamanishi Koichi
Nakamura Yuki
書名別名 再発性帯状疱疹の臨床的、免疫学的特徴
出版元 Elsevier
刊行年月 1979-
ISSN 01909622
NCID AA00256724
※クリックでCiNii Booksを表示
言語 英語
出版国 アメリカ合衆国
この本を: 
このエントリーをはてなブックマークに追加

このページを印刷

外部サイトで検索

この本と繋がる本を検索

ウィキペディアから連想