Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis

To investigate the molecular mechanisms of cancer metastasis, we have isolated a high-metastatic bladder cancer cell subpopulation from a low-metastatic cell line by using an in vivo selection system. Cells in the subpopulation showed a high ability to form invadopodia, the filamentous actin (F-actin)-based membrane protrusions that play an essential role in cancer cell invasion. Analysis of the gene expression profile revealed that the expression of an intermediate filament (IF) protein, vimentin and a cytoskeletal linker protein, plectin was up-regulated in the high-metastatic subpopulation compared with the low metastatic cell line. Here we report a novel role of vimentin IF and plectin in metastasis. In invasive bladder cancer cells, the vimentin IF-plectin-invadopodia F-actin link was formed. Disruption of this link severely impaired invadopodia formation, reducing the capacities of extracellular matrix degradation, transendothelial migration and metastasis. In addition, the vimentin assembly into the filaments was required for invadopodia formation. Our results suggest that plectin anchoring invadopodia to vimentin IF scaffolds and stabilizes invadopodia, which is a critical molecular process for cancer cell invasion and extravasation for metastasis.;掲載誌本文リンク:http://www.sciencedirect.com/science/article/pii/S017193351400048X;開始ページ : 157;終了ページ : 169

「国立国会図書館デジタルコレクション(雑誌)」より

この本の情報

書名 Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis
著作者等 Deutsche Gesellschaft für Elektronenmikroskopie
Deutsche Gesellschaft für Zellbiologie
European Cell Biology Organization
Yoneyama Mihoko
書名別名 ビメンチン中間径フィラメントとプレクチンによる浸潤突起の足場形成は癌転移のための浸潤および血管外脱出過程を促進する
出版元 Elsevier
ページ数 v.
大きさ 28 cm
ISSN 01719335
NCID AA00181272
AA12083725
※クリックでCiNii Booksを表示
この本を: 
このエントリーをはてなブックマークに追加

Yahoo!ブックマークに登録
この記事をクリップ!
Clip to Evernote
このページを印刷

外部サイトで検索

この本と繋がる本を検索

ウィキペディアから連想