Adjuvant Hepatic Arterial Infusion Chemotherapy After Resection for Pancreatic Cancer Using Coaxial Catheter-Port System Compared with Conventional System.

PURPOSE: Previous reports have shown the effectiveness of adjuvant hepatic arterial infusion chemotherapy (HAIC) in pancreatic cancer. However, percutaneous catheter placement is technically difficult after pancreatic surgery. The purpose of this study was to evaluate the feasibility and outcome of HAIC using a coaxial technique compared with conventional technique for postoperative pancreatic cancer. MATERIALS AND METHODS: 93 consecutive patients who received percutaneous catheter-port system placement after pancreatectomy were enrolled. In 58 patients from March 2006 to August 2010 (Group A), a conventional technique with a 5-Fr indwelling catheter was used and in 35 patients from September 2010 to September 2012 (Group B), a coaxial technique with a 2.7-Fr coaxial catheter was used. RESULTS: The overall technical success rates were 97.1 % in Group B and 86.2 % in Group A. In cases with arterial tortuousness and stenosis, the success rate was significantly higher in Group B (91.7 vs. 53.8 %; P = 0.046). Fluoroscopic and total procedure times were significantly shorter in Group B: 14.7 versus 26.7 min (P = 0.001) and 64.8 versus 80.7 min (P = 0.0051), respectively. No differences were seen in the complication rate. The 1 year liver metastasis rates were 9.9 % using the conventional system and 9.1 % using the coaxial system (P = 0.678). The overall median survival time was 44 months. There was no difference in the survival period between two systems (P = 0.312). CONCLUSIONS: The coaxial technique is useful for catheter placement after pancreatectomy, achieving a high success rate and reducing fluoroscopic and procedure times, while maintaining the safety and efficacy for adjuvant HAIC in pancreatic cancer.;博士(医学)・乙第1380号・平成28年7月8日;© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2016;The final publication is available at Springer via http://dx.doi.org/10.1007/s00270-016-1292-7;開始ページ : 831;終了ページ : 839;PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/26762632

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書名 Adjuvant Hepatic Arterial Infusion Chemotherapy After Resection for Pancreatic Cancer Using Coaxial Catheter-Port System Compared with Conventional System.
著作者等 Cardiovascular and Interventional Radiological Society of Europe
European College of Angiography
European Society of Cardiovascular and Interventional Radiology
North American Society for Cardiac Radiology
Society of Cardiovascular Radiology
日本血管造影・インターベンショナルラジオロジー学会
Anai Hiroshi
Hasegawa Masatoshi
Kanno Masatoshi
Kichikawa Kimihiko
Marugami Nagaaki
Masada Tetsuya
Nakajima Yoshiyuki
Nishiofuku Hideyuki
Sakaguchi Hiroshi
Sato Takeshi
Sho Masayuki
Tamamoto Tetsuro
Tanaka Toshihiro
Hashimoto Aya
書名別名 膵癌術後予防肝動注におけるリザーバー留置術の検討 : 従来法とcoaxialシステムの比較
出版元 Springer-Verlag
ページ数 v.
大きさ 28 cm
ISSN 01741551
NCID AA00141846
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言語 英語
出版国 ドイツ
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