Retrospective diagnosis of congenital cytomegalovirus infection in children with autism spectrum disorder but no other major neurologic deficit

Aim: Congenital cytomegalovirus (CMV) infection can cause a variety of neurological deficits of delayed onset in infants who are asymptomatic at birth. The aim of this study was to investigate the prevalence of congenital CMV infection among children with autism spectrum disorder (ASD) in Nagasaki, Japan. Methods: Twenty-nine children with ASD who were born in Nagasaki and had no other major neurological deficits were recruited. Two of the patients were excluded due to significant perinatal events. The remaining 27 children were investigated retrospectively for congenital CMV infection by analyzing dried blood spot samples or dried umbilical cords for CMV DNA using real-time PCR. Results: CMV DNA was detected in two (7.4%) of the 27 children. Neither of the patients had perinatal histories suggestive of congenital CMV disease or other neurological deficits, including hearing impairment and epilepsy. The severity of their autistic disorders varied considerably. Conclusions: The rate of congenital CMV infection in this study (two of 27 children with ASD), which was significantly (p = 0.004) higher than the incidence of congenital CMV infection in Nagasaki (0.31%, 10/3230 live births), suggests the involvement of congenital CMV infection in a portion of children with ASD, although definite diagnosis was not obtained due to limited clinical data of the study subjects.;開始ページ : 200;終了ページ : 205;元資料の権利情報 : © 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V.;元資料の権利情報 : NOTICE: this is the author's version of a work that was accepted for publication in Brain and Development. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Brain and Development, 37, 2, (2015)

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書名 Retrospective diagnosis of congenital cytomegalovirus infection in children with autism spectrum disorder but no other major neurologic deficit
著作者等 Elsevier Science Publishers
日本小児神経学会
坂本 綾子
書名別名 他には目立った神経学的異常を認めない自閉症スペクトラム障害の小児における先天性サイトメガロウイルス感染の後方視的診断
出版元 日本小児神経学会
刊行年月 1979-
ページ数 v.
大きさ 28 cm
ISSN 03877604
NCID AA00111153
AA11521714
※クリックでCiNii Booksを表示
全国書誌番号
10023319
※クリックで国立国会図書館サーチを表示
言語 英語
出版国 日本
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