Originals Cephalosporin Antibiotics III. Facile Acylation with Phosphoryl Chloride / Eiji NAKAYAMA
Koichi FUJIMOTO
Shigeki MURAMATSU
Junya IDE / p83～92
Originals Contribution of Polymorphonuclear-leukocyte Adherence to Transendothelial Migration and Injury of Endothelial Cells / Seiichiro KUMAKURA
Noriko AMAGAI
Yoshio IIZUKA / p93～102
Originals Involvement of Leukotriene D₄ in Pulmonary Eosinophilia and Eosinophil Activation in Guinea Pigs / Kazuhiro ITOH
Osamu MUKAIYAMA
Yumiko SATOH
Takeshi YAMAGUCHI / p103～117
Originals Apiodionen, Inhibitor of Topoisomerase and Suppressor of Chemiluminescence: Taxonomy, Fermentation, Isolation, Structural Elucidation and Biological Activity / Shuji TAKAHASHI
Takeshi KAGASAKI
Kouhei FURUYA
Yoshio IIZUKA
Noriko AMAGAI
Sachiko NAITO
Akio SHIRAISHI / p119～127
Originals Isolation and Structural Elucidation of Preapiodionen, the Precursor of Apiodionen / Shuji TAKAHASHI / p129～133
Notes Structure of a Dimer of α-Thioxoketone Produced by Novel Fragmentation Reaction of 2-[2-(Methanesulfonyloxy) ethylthio]-2', 4'-dichloropropiophenone / Makoto MORI
Sadao OIDA / p135～140
Notes Reactivity of Some Benzothiazepine Derivatives / Koichi HIRAI
Yuji IWANO
Isamu MIKOSHIBA
Hiroshi HOMMA / p141～150
Notes Determination of Absolute Configuration by Anomalous Scattering of Light Atoms: A Study into the Limitations of this Method / Hiroyuki HANZAWA
Tadashi HATA / p151～160
Abstracts of papers published in other publications / / p161～252
Physical & Analytical Chemistry A Sensitive Nonisotopic Method for the Determination of Intracellular Azidothymidine 5'-mono-, 5'-di-, and 5'-Triphosphate / Takuo TOYOSHIMA
Satoshi KIMURA
Shigeki MURAMATSU
Hidekuni TAKAHAGI
Kaoru SHIMADA / p161～161
Physical & Analytical Chemistry Crystal and Molecular Structure of 2'-Deoxy-2'-(R)-phenylsulfinyluridine / Tadashi HATA
Akira MATSUDA
Tadashi MIYASAKA / p161～162
Physical & Analytical Chemistry Crystal and Molecular Structure of 2'-Deoxy-2'-(S)-phenylsulfinyluridine Hemihydrate / Tadashi HATA
Akira MATSUDA
Tadashi MIYASAKA / p162～162
Physical & Analytical Chemistry Nondestructive in situ Ftir Measurement by Diffuse Reflectance Spectrometry--Penetration Depth, Surface Measurement and Interior Analysis / Teiki IWAOKA
Shinya TSUTSUMI
Fumiko TABATA / p162～162
Physical & Analytical Chemistry New Analytical Method for Measuring Radioactivities of Blood Using Imaging Plate System / Eiichi NAKAJIMA
Yoshie YASUKAWA
Kazunori ONO
Kenji KAWAI
Hayao SHINOZAKI / p163～163
Physical & Analytical Chemistry Application of Electrospray Ionization-Liquid Chromatography/Mass Spectrometry (ESI-LC/MS) on Drug Metabolism (I) / Nobuhiro KOBAYASHI
Haruo IWABUCHI
Akihiko NAKAGAWA
Eiichi KITAZAWA
Kan-ichi NAKAMURA / p163～163
Physical & Analytical Chemistry Structual Analysis of Non-volatile Compounds by Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/Tandem Mass Spectrometry: Thermal Isomerization of Benzylpenicillin in Plasmaspray Interface / Yasuko OHKI
Takemichi NAKAMURA
Hidemi NAGAKI
Takeshi KINOSHITA / p163～164
Physical & Analytical Chemistry Structural Study of Triazole Antifungals.II. Crystal and Molecular Structures of the Two Diastereoisomers(4R*,5R*)-and(4S*,5R*)-5-(2,4-Difluorophenyl)-4-methyl-5-[(1H-1,2,4-triazol-1-y1)methyl] -3-[4-(trifluoromethyl)benzoyl]oxazolidine / Tadashi HATA
Youji FURUKAWA
Toshiyuki KONOSU
Sadao OIDA / p164～164
Physical & Analytical Chemistry Ion Chromatography of Inorganic Anions Using a Simplified Suppressor / Hisomu NAGASHIMA
Takeshi OHTSUKA
Akinori ISOZAKI / p165～165
Physical & Analytical Chemistry Quantitative Autoradiography in Brain Research--Application of Imaging Plate Method / Eiichi NAKAJIMA / p165～166
Physical & Analytical Chemistry 3-Bromomethyl-7-methoxy-1,4-benzoxazin-2-one as a Highly Sensitive Fluorescence Derivatization Reagent for Carboxylic Acids in High-performance Liquid Chromatography / Akio NAKANISHI
Hideo NAGANUMA
Junichi KONDO
Keiko WATANABE
Kimie HIRANO
Takao KAWASAKI
Yukinori KAWAHARA / p166～166
Physical & Analytical Chemistry Preparation of Immunoaffinity Mini-column for the Analysis of Platelet Activating Factor(PAF)in Biological Samples / Masako WATANABE
Takanori WATANABE
Noriyasu HIRASAWA
Suetsugu MUE
Shigeki MURAMATSU
Yoko MATSUSHITA
Hidekuni TAKAHAGI
Pierre BRAQUET
Collette BRAQUET
Lawrence LEVINE
Kazuo OHUCHI / p166～167
Organic Chemistry Synthesis of 2-Deoxy-2-[(3R)-3-hydroxytetradecanamido]-3-O-[(3R)-3-hydroxytetradecanyl]-a-D-glucopyranosyl Dihydrogen Phosphate and 2-Deoxy-2-[(3R)-3-hydroxytetradecanamido]-3-O-[(3R)-3-hydroxytetradecanyl]-4-O-phosphono-D-glucopyranose / Masao SHIOZAKI
Yoshiyuki KOBAYASHI
Noboru ISHIDA
Masami ARAI
Tetsuo HIRAOKA
Masahiro NISHIJIMA
Sayuri KUGE
Toshiaki OTSUKA
Yuzuru AKAMATSU / p167～167
Organic Chemistry Synthesis of a 3-Ether Analogue of Lipid A / Masao SHIOZAKI
Yoshiyuki KOBAYASHI
Masami ARAI
Noboru ISHIDA
Tetsuo HIRAOKA
Masahiro NISHIJIMA
Sayuri KUGE
Toshiaki OTSUKA
Yuzuru AKAMATSU / p167～168
Organic Chemistry Syntheses of 2,6-Dideoxy-6-fluoro-2-[(3R and 3S)-3 hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)-tetradecanoyl]-D-glucopyranose 4- (dihydrogen phosphate)and 2-deoxy-2-[(3R and 3S)-3-hydroxytetradecanamido] -3-O- [(3R)-3-(tetradecanoyloxy)tetradecanoyl]-a-D-glucopy-ranosyl Fluoride 4-(Dihydrogen phosphate): Fluor-osugar Analogues of GLA-60 / Yoshiyuki KOBAYASHI
Noboru ISHIDA
Masami ARAI
Masao SHIOZAKI
Tetsuo HIRAOKA
Masahiro NISHIJIMA
Sayuri KUGE
Toshiaki OTSUKA
Yuzuru AKAMATSU / p168～168
Organic Chemistry Design and Synthesis of Highly Specific and Selective Enkephalin Analog Containing S-Npys-Cysteine for δ Opioid Receptors / Rei MATSUEDA
Teruo YASUNAGA
Hiroaki KODAMA
Michio KONDO
Tommaso COSTA
Yasuyuki SHIMOHIGASHI / p169～169
Organic Chemistry Enantiocontrolled Synthesis of the Antifungal β Lactam (2R,5S)-2-(Hydroxymethyl) clavam / Toshiyuki KONOSU
Sadao OIDA / p169～169
Organic Chemistry Triazole Antifungals.III. Stereocontrolled Synthsis of an Optically Active Triazolylmethyloxirane Precursor to Antifungal Oxazolidine Derivatives / Toshiyuki KONOSU
Takeo MIYAOKA
Yawara TAJIMA
Sadao OIDA / p170～170
Organic Chemistry Triazole Antifungals.IV. Synthesis and Antifungal Activities of 3-Acylamino-2-aryl-2-butanol Derivatives / Toshiyuki KONOSU
Yawara TAJIMA
Noriko TAKEDA
Takeo MIYAOKA
Mayumi KASAHARA
Hiroshi YASUDA
Sadao OIDA / p170～171
Organic Chemistry β-Lactam Antifungals.II. Enantiocontrolled Synthesis of (2R,5S)-2-Hydroxymethyl-1-carbapenam,the Carba-Analog of a Clavam Antifungal / Toshiyuki KONOSU
Yoji FURUKAWA
Tadashi HATA
Sadao OIDA / p171～171
Organic Chemistry Synthesis of 2-Deoxy-2-[(2S,3R)-(2-fluoro-3-hydro-xytetradecanoyl)amino] -3-O-[(3R)-3-tetradecanoy-loxytetradecanoyl]-D-glucopyranose 4-(Dihydrogen Phosphate) and 2-Deoxy-2- [(2R,3S)-(2-fluoro-3-hydroxytetradecanoyl)amino] -3-O-[(3R)-3-tetrade canoyloxytetradecanoyl]-D-glucopyranose 4-(Dihydrogen Phosphate) / Yoshiyuki KOBAYASHI
Noboru ISHIDA
Masami ARAI
Masao SHIOZAKI
Tetsuo HIRAOKA
Masahiro NISHIJIMA
Sayuri KUGE*
Toshiaki OTSUKA
Yuzuru AKAMATSU / p171～172
Organic Chemistry Payne Rearrangement Route to the Optically Active Oxirane Precursor for the Preparation of Triazole Antifungals / Toshiyuki KONOSU
Takeo MIYAOKA
Yawara TAJIMA
Sadao OIDA / p172～172
Organic Chemistry A Palladium-Catalyzed,Abnormal Hydrogenolytic Ring-Cleavage Reaction of Fused β-Lactams / Toshiyuki KONOSU
Sadao OIDA / p173～173
Organic Chemistry Triazole Antifungals.V. Synthesis and Antifungal Activities of Some Amides Related to 3-Acylamino-2-aryl-1-triazolyl-2-butanol / Teruo TANAKA
Noriko TAKEDA
Toshiyuki KONOSU
Hiroshi YASUDA
Sadao OIDA / p173～174
Organic Chemistry Synthesis and Antihypertensive Activity of 3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (Diltiazem) Derivatives Having Substituents at the 8 Position / Hiroaki YANAGISAWA
Koichi FUJIMOTO
Yasuo SHIMOJI
Takuro KANAZAKI
Kanako MIZUTARI
Hiroshi NISHINO
Hiroshi SHIGA
Hiroyuki KOIKE / p174～174
Organic Chemistry Synthesis of Fused Aminotetrahydrocarbazole Compounds / Yasuo SHIMOJI
Fujio SAITO
Kuniyuki TOMITA
Yasuhiro MORISAWA / p174～175
Organic Chemistry Applications of an Asymmetric[2+2]-Photocyclo-addition. Total Synthesis of (-) Echinosporin. Construction of an Advanced 11-Deoxyprostaglandin Intermediate / Amos B. SMITH III
Gary A. SULIKOWSKI
Michelle M. SULIKOWSKI
Katsumi FUJIMOTO / p175～176
Organic Chemistry Synthesis and Antibacterial Activities of New 3-Phenoxymethylcephalosporins / Kazuo KOYAMA
Shinichi SAITO
Koichi KOJIMA / p176～176
Organic Chemistry Synthesis and Antibacterial Activity of 7-[2-(2-Aminooxazol-4-yl)-(Z)-2-alkoxyiminoacetamido] cephalosporin Antibiotics / Eiji NAKAYAMA
Koichi FUJIMOTO
Shigeki MURAMATSU
Junya IDE / p176～176
Organic Chemistry Synthesis and Biological Action of the Aminotetra-hydroisoquinocarbazoles and Related Compounds: A New Class of Compounds with Antiarrhythmic Activity / Yasuo SHIMOJI
Kuniyuki TOMITA
Toshihiko HASHIMOTO
Fujio SAITO
Yasuhiro MORISAWA
Hiroshi MIZUNO
Ryosuke YORIKANE
Hiroyuki KOIKE / p177～177
Organic Chemistry Novel SN2'-Type Reaction of β-(Silyl)allylic Ethers with Alkyllithiums: A Stereoselective Entry to (E)-Vinylic Silanes / Naoyuki KISHI
Hironori IMMA
Koichi MIKAMI
Takeshi NAKAI / p177～178
Organic Chemistry Synthesis of (2R,3S)-3-[(Benzyloxycarbonyl)oxy]- 2-fluorotetradecanoic Acid / Masao SHIOZAKI
Yoshiyuki KOBAYASHI
Masami ARAI / p178～178
Organic Chemistry Vinylsilane-Terminated Cycloacylation:A General Synthetic Approach to Four-to Six-Membered Cyclic Ketones and its Regiochemical Features / Naoyuki KISHI
Koichi MIKAMI
Takeshi NAKAI / p178～179
Organic Chemistry [2,3]Wittig Rearrangement-Peterson Olefination Sequence:A Stereocontrolled Entry to Terminal Conjugated Trienes / Naoyuki KISHI
Organic Chemistry Assignment of (6R*,10R*)-Relative Stereochemistry to the Major Component of the Sex Pheromone of the Maritime Pine Scale,Matsucoccus feytaudi / Kenji MORI
Susumu HARASHIMA / p180～180
Organic Chemistry Concise Synthesis of Optically Active Oxirane Precursors for the Preparation of Triazole Antifungals Using the Friedel-Crafts Reaction of (S)-2-Tosyloxypropionyl Chloride / Toshiyuki KONOSU
Yawara TAJIMA
Takeo MIYAOKA
Sadao OIDA / p180～181
Organic Chemistry Recent Development on the Studies of Nucleic Acid Antitumor Antimetabolites / Masakatsu KANEKO / p181～182
Organic Chemistry Recent Advances in the Field of the β-Lactam Ring Formation Reaction from the Aspect of the Synthetic Chemistry II / Koichi HIRAI / p182～182
Natural Chemistry A Farnesyl Arabinoside as an Enhancer of Glucose Transport in Rat Adipocytes from a Soft Coral, Sinularia sp / Takamasa SHINDO
Aiya SATO
Hiroyoshi HORIKOSHI
Harumitsu KUWANO / p182～183
Natural Chemistry Keramamide B-D: Novel Peptides from the Okinawan Marine Sponge Theonella sp / Jun'ichi KOBAYASHI
Fumio ITAGAKI
Hideyuki SHIGEMORI
Masami ISHIBASHI
Kazuhiko TAKAHASHI
Michiko OGURA
Shigeharu NAGASAWA
Takemichi NAKAMURA
Hiroshi HIROTA
Tomihisa OHTA
Shigeo NOZOE / p183～183
Natural Chemistry Keramamide A,a Novel Peptide from the Okinawan Marine Sponge Theonella sp / Jun'ichi KOBAYASHI
Masaaki SATO
Masami ISHIBASHI
Hideyuki SHIGEMORI
Takemichi NAKAMURA
Yasushi OHIZUMI / p183～184
Genetics Genomic Organization of the Human Homologue of the Rat Pancreatic Elastase I Gene / Ichiro KAWASHIMA
Tokio TANI
Katsuko MITA-HONJO
Kumi SHIMODA-TAKANO
Toshinori OHMINE
Hidehiko FURUKAWA
Yo TAKIGUCHI / p184～184
Genetics Characterization of the Primate-specific Repetitive DNA Element MERI / Ichiro KAWASHIMA
Katsuko MITA-HONJO
Yo TAKIGUCHI / p185～185
Genetics NMDA Receptor Cloned / Jun HARADA / p185～185
Genetics Adipogenesis Inhibitory Factor A Novel Inhibitory Regulator of Adipose Conversion in Bone Marrow / Jun OHSUMI
Kenji MIYADAI
Ichiro KAWASHIMA
Hiroko ISHIKAWA-OHSUMI
Sachiko SAKAKIBARA
Katsuko MITA-HONJO
Yo TAKIGUCHI / p185～186
Genetics Novel Adipogenesis Inhibitory Factor (AGIF):Its Structure and Function / Ichiro KAWASHIMA
Jun OHSUMI
Kenji MIYADAI
Katsuko MITA-HONJO
Hiroko ISHIKAWA-OHSUMI
Sachiko SAKAKIBARA
Kumi SHIMODA-TAKANO
YO TAKIGUCHI / p186～186
Genetics Evidence For The Involvement of Protein Kinase Activity In Transforming Growth Factor-β Signal Transduction / Masahiko OHTSUKI
Joan MASSAGUE / p186～187
Genetics A Protein Required for RNA Processing and Splicing in Neurospora Mitochondria is Related to Gene Products Involved in Cell Cycle Protein Phosphatase Functions / Beatrice TURCQ
Katherine F.DOBINSON
Nobufusa SERIZAWA
Alan M. LAMBOWITZ / p187～188
Biochemistry The Role of Insulin-Sensitive Phosphodiesterase in Insulin Action / Hideichi MAKINO
Takashi SUZUKI
Hiroshi KAJINUMA
Mitsuo YAMAZAKI
Hiroko ITO
Sho YOSHIDA / p188～188
Biochemistry Properties of Base-Substituted and Carboxyl Esterified Analogues of Griseolic Acid,a Potent cAMP Phosphodiesterase Inhibitor / Takashi YASUMOTO
Yasuteru IIJIMA
Masakatsu KANEKO
Mitsuo YAMAZAKI / p188～189
Biochemistry Subcellular Distribution and Phosphorylation State of Insulin Receptors from Insulin- and Isoproterenol- Treated Rat Adipose Cells / T.M. WEBER
H.G. JOOST
Masao KURODA
S.W. CUSHMAN
I.A. SIMPSON / p189～189
Biochemistry A Cyclic AMP Phosphodiesterase Inhibitor,8'-Pivaloyloxymethyl Ester (POM-ester) of Griseolic Acid,Lowers Rabbit Intraocular Pressure / Hiromu K. MISHIMA
Yoshiaki KIUCHI
Tomihisa YOKOYAMA
Takashi YASUMOTO
Mitsuo YAMAZAKI / p190～190
Biochemistry Studies on Griseolic Acid Derivatives X. Synthesis and Phosphodiesterase Inhibitory Activity of 2-Substituted Derivatives of Griseolic Acid / Masakatsu KANEKO
Misako KIMURA
Yoshinobu MUROFUSHI
Takashi YASUMOTO
Yasuteru IIJIMA
Mitsuo YAMAZAKI / p190～191
Biochemistry Protein Kinase C Family and Nervous Function / Yasumi NISHIZUKA
M.S. SHEARMAN
Tomiichiro ODA
N. BERRY
Tetsutaro SHINOMURA
Yoshinori ASAOKA
Koji OGITA
Hiroshi KOIDE
Uzuru KIKKAWA
Akira KISHIMOTO
A. KOSE
N. SAITO
Chikako TANAKA / p192～192
Biochemistry Enzyme Immunoassay of Human Plasma 11-Dehydrothromboxane B₂ / Wataru TAKASAKI
Akihiko NAKAGAWA
Yorihisa TANAKA
Kan-ichi NAKAMURA
Hideyo SHINDO
Yoko HAYASHI
Shozo YAMAMOTO / p192～193
Microbiology & Fermentation Susceptibility of Pseudomonas Species to the Novel Antibiotics Mureidomycins / Fujio ISONO
Kentaro KODAMA
Masatoshi INUKAI / p193～193
Microbiology & Fermentation Induction of Ploidy Level Increments in an Asporogenous Industrial Strain of the Yeast Saccharomyces cerevisiae by UV Irradiation / Takashi SASAKI / p193～194
Microbiology & Fermentation Enumeration of the Helotiales from the Sugadaira Montane Research Center and its Environs / Tsuyoshi HOSOYA
Yoshio OTANI
Kouhei FURUYA / p194～194
Microbiology & Fermentation Structural Elucidation of Aculeximycin.I. Further Purification and Glycosidic Bond Cleavage of Aculeximycin / Hideaki MURATA
Noriko KOJIMA
Ken-ichi HARADA
Takaya IKEMOTO
Toshiro SHIBUYA
Makoto SUZUKI
Tatsuo HANEISHI
Akio TORIKATA / p194～195
Microbiology & Fermentation Structural Elucidation of Aculeximycin.II. Structures of Carbohydrate Moieties / Hideaki MURATA
Ken-ichi HARADA
Makoto SUZUKI
Takaya IKEMOTO
Toshiro SHIBUYA
Tatsuo HANEISHI
Akio TORIKATA / p195～196
Microbiology & Fermentation Cornexistin : A New Fungal Metabolite with Herbicidal Activity / Mutsuo NAKAJIMA
Kazuko ITOI
Yasuyuki TAKAMATSU
Sadao SATO
Youji FURUKAWA
Kouhei FURUYA
Toyokuni HONMA
Junji KADOTANI
Makoto KOZASA
Tatsuo HANEISHI / p196～196
Microbiology & Fermentation Trehazolin, a New Trehalase Inhibitor / Osamu ANDO
Hitomi SATAKE
Kazuko ITOI
Akira SATO
Mutsuo NAKAJIMA
Shuji TAKAHASHI
Hideyuki HARUYAMA
Yoshiko OHKUMA
Takeshi KINOSHITA
Ryuzo ENOKITA / p196～197
Microbiology & Fermentation Galacardins A and B, New Glycopeptide Antibiotics / Michiko TAKEUCHI
Shuji TAKAHASHI
Ryuzo ENOKITA
Yoshiharu SAKAIDA
Hideyuki HARUYAMA
Takemichi NAKAMURA
Toshiaki KATAYAMA
Masatoshi INUKAI / p197～197
Microbiology & Fermentation Biosynthesis of Griseolic Acids:Incorporation of¹³C-Labeled Compounds into Griseolic Acid A / Shunichi MIYAKOSHI
Hideyuki HARUYAMA
Tetsuya SHIOIRI
Shuji TAKAHASHI
Akio TORIKATA
Mitsuo YAMAZAKI / p197～198
Microbiology & Fermentation Microbial Conversion of Milbemycins:29-Hydroxylation of Milbemycins by Genus Syncephalastrum / Keiko NAKAGAWA
Kazuo SATO
Yoshihisa TSUKAMOTO
Akio TORIKATA / p198～198
Microbiology & Fermentation Leualacin, a Novel Calcium Blocker from Hapsidospora Irregularis I. Taxonomy, Fermentation, Isolation, Physico-chemical and Biological Properties / Kiyoshi HAMANO
Masako KINOSHITA
Kouhei FURUYA
Masaaki MIYAMOTO
Yasuyuki TAKAMATSU
Atsuko HEMMI
Kazuhiko TANZAWA / p199～199
Microbiology & Fermentation Leualacin, a Novel Calcium Blocker from Hapsidospora Irregularis II. Structure Determination / Kiyoshi HAMANO
Masako KINOSHITA
Kazuhiko TANZAWA
Keiko YODA
Yasuko OHKI
Takemichi NAKAMURA
Takeshi KINOSHITA / p199～200
Microbiology & Fermentation Micellaneous Notes on Japanese Discomycetes(II) / Yoshio OTANI
Tsuyoshi HOSOYA
Kouhei FURUYA / p200～200
Microbiology & Fermentation Materials for the Fungus Flora of Japan(44) / Tsuyoshi HOSOYA
Toxicology Toxicological Studies of Panipenem/betamipron-Acute Toxicity Studies in Rats with a Single Intravenous Administration / Kunio KIMURA
Shigeo TOTSUKA
Yuji SAITO
Masahiro MORI / p201～202
Toxicology Subacute Toxicological Study in Rats Treated Intravenously with Panipenem for 90 Days / Sunao MANABE
Kunio KIMURA
Shigeo TOTSUKA
Etsuji MATSUMOTO
Naochika MATSUNUMA
Hiroshi MASUDA / p202～202
Toxicology Subacute Toxicological Study in Rats Treated Intravenously with Panipenem/betamipron for 90 Days / Sunao MANABE
Kunio KIMURA
Etsuji MATSUMOTO
Takashi YAMOTO
Naochika MATSUNUMA
Hiroshi MASUDA / p202～203
Toxicology Safety Evaluation of HMG-CoA Reductase Inhibitor-Nonclinical Study-Effects on Sex Hormones / Hiroshi MASUDA / p203～204
Toxicology Long Term Observation in Beagles Treated with Escalating Dose of Alloxan / Chitoshi TARUMI
Kenichi NAGATA
Masaya TAKAOKA
Hiroshi MASUDA / p204～204
Toxicology The Acute Toxicity Study of Temocapril Hydrochloride (CS-622) / Kunio KIMURA
Shigeo TOZUKA
Takayuki SATO
Akinaga SUGANO
Sunao MANABE
Masahiro MORI / p205～205
Toxicology Subacute Toxicological Study in Rats Treated Orally with Temocapril Hydrochloride (CS-622) for 90 Days and Recovery Study for 28 Days / Masaya TAKAOKA
Kunio KIMURA
Kazuo YAMASHITA
Nobuhiro MIYAKOSHI
Sunao MANABE
Naochika MATSUNUMA
Hiroshi MASUDA / p205～206
Toxicology Chronic Toxicological Study in Rats Treated Orally with Temocapril Hydrochloride (CS-622) for One Year / Masaya TAKAOKA
Kunio KIMURA
Kazuo YAMASHITA
Nobuhiro MIYAKOSHI
Sunao MANABE
Naochika MATSUNUMA
Hiroshi MASUDA / p206～207
Toxicology Reproductive and Developmental Toxicity Study on Temocapril Hydrochloride (CS-622) Administered during the Period of Fetal Organogenesis in Rabbits / Hisao TANASE
Munenori ASAI
Koichi HIROSE / p207～208
Toxicology Antigenicity Studies on Temocapril Hydrochloride (CS-622) in Guinea Pigs and Mice / Kenkichi SHINKAI
Tsutomu KIMURA
Nobuhiro ISHIKAWA
Yukiko KURITA
Keiko MURAMATSU
Kazuo YAMASHITA / p208～208
Antimicrobials Inhibition of Human Immunodeficiency Virus Type-1-induced Syncytium Formation and Cytopathicity by Complestatin / Kenji MOMOTA
Isao KANEKO
Satoshi KIMURA
Keiji MITAMURA
Kaoru SHIMADA / p209～209
Antimicrobials In vitro and in vivo Antibacterial Activity of Panipenem/betamipron, a New Carbapenem Antibiotic / Takeshi NISHINO
Takashi FUKUOKA
Takuya HONMURA
Yumiko NISHIGUCHI
Masako OTSUKI / p209～210
Antimicrobials Microbiological Evaluation of Panipenem/betamipron, a New Parenterally Active Carbapenem I. In vitro Antibacterial Activities / Yukio UTSUI
Satoshi OHYA
Haruki DOMON
Mitsuo KATSUTA
Takashi TAKENOUCHI
Yohko AJIKI
Naoko SEKINE
Mayumi KASAHARA
Teruo NARITA
Masazoh TAJIMA
Hiroshi YASUDA
Shogo KUWAHARA / p210～211
Antimicrobials Microbiological Evaluation of Panipenem/betamipron, a New Parenterally Active Carbapenem II. Mechanism of Antibacterial Activity of Panipenem / Satoshi OHYA
Yukio UTSUI
Tsutomu YAJIMA
Haruki DOMON
Takashi TAKENOUCHI
Takashi FUKUOKA
Yoko AJIKI
Naoko SEKINE
Harumi KAWADA
Hiroshi YASUDA
Shogo KUWAHARA / p211～212
Antimicrobials Microbiological Evaluation of Panipenem/betamipron, a New Parenterally Active Carbapenem III. In Vivo Antibacterial Activities / Teruo NARITA
Mitsuo KATSUTA
Takashi TAKENOUCHI
Takashi FUKUOKA
Tetsufumi KOGA
Yoko AJIKI
Mayumi KASAHARA
Masako IIJIMA
Hiroshi YASUDA
Shogo KUWAHARA / p212～213
Antimicrobials Microbiological Evaluation of Panipenem/betamipron, a New Parenterally Active Carbapenem IV. Antipseudomonal Activity of Panipenem Compared with That of Imipenem / Satoshi OHYA
Takashi FUKUOKA
Tsutomu YAJIMA
Takashi TAKENOUCHI
Yoko AJIKI
Naoko SEKINE
Hiroshi YASUDA
Shogo KUWAHARA / p213～213
Antimicrobials Microbiological Evaluation of Panipenem/betamipron, a New Parenterally Active Carbapenem V. Increase in Susceptibility of Pseudomonas aeruginosa to Panipenem in Low-Amino-Acid Media / Satoshi OHYA
Takashi FUKUOKA
Nobuhisa MASUDA
Takashi TAKENOUCHI
Naoko SEKINE
Masako IIJIMA
Hiroshi YASUDA
Shogo KUWAHARA / p214～214
Antimicrobials Influence of Repeated Intravenous Infusions of Panipenem/betamipron on the Fecal Microflora of Healthy Volunteers / Satoshi OHYA
Haruki DOMON
Mitsuo KATSUTA
Tsutomu YAJIMA
Yukio UTSUI
Takashi TAKENOUCHI
Takashi FUKUOKA
Yoko AJIKI
Naoko SEKINE
Mayumi KASAHARA
Hiroshi YASUDA
Kunitomo WATANABE
Kazue UENO / p214～215
Antimicrobials β-Lactamase Produced by a Highly β-Lactamresistant Strain of Bacteroides fragilis:an Obstacle to the Chemotherapy of Experimental Mixed Infections / Yohko AJIKI
Tetsufumi KOGA
Satoshi OHYA
Takashi TAKENOUCHI
Hiroshi YASUDA
Kunitomo WATANABE
Kazue UENO / p215～216
Antimicrobials Antibacterial Activity of Cefpodoxime against Branhamella catarrhais / Takashi TAKENOUCHI
Pharmacology Pharmacological Characteristics of New Antidiabetic Agent CS-045 in Diabetic Animals / Hiroyoshi HORIKOSHI
Toshihiko FUJIWARA
Takao YOSHIOKA
Shinji YOSHIOKA
Mikiyo WADA
Masaharu FUKAMI / p219～220
Pharmacology Effects of Repeated Oral Administration of Renin Inhibitor ES-8891 on the Renin-Angiotensin System in Human Subjects / Eiki MURAKAMI
Tatsuo KOKUBU
Yasuko II
Kunio HIWADA
Shigeki MURAMATSU
Hidekuni TAKAHAGI
Patrick F. SALMON / p220～220
Pharmacology Electrophysiological Effects of Endothelin-1 on Canine Myocardial Cells / Ryosuke YORIKANE
Hiroyuki KOIKE
Shigeki MIYAKE / p220～221
Pharmacology Cyclic Nucleotide-dependent Regulation of Agonist-induced Calcium Increases in Mouse Megakaryocytes / Masahiro IKEDA
Kiyoshi KUROKAWA
Yoshio MARUYAMA / p221～222
Pharmacology Recombinant Human Erythropoietin, but not Iron Supplementation, Improves Anemia in Rats with Adjuvant-induced Arthritis / Fumitoshi ASAI
Takeshi OSHIMA / p222～222
Pharmacology Effects of Pravastatin Sodium Alone and in Combination with Cholestyramine on Hepatic and Adrenal Low Density Lipoprotein Receptors on Homozygous Watanabe Heritable Hyperlipidemic Rabbits / Masao KURODA
Akiyo MATSUMOTO
Hiroshige ITAKURA
Yoshio WATANABE
Takashi ITO
Masashi SHIOMI
Junichiro FUKUSHIGE
Futoshi NARA
Masaharu FUKAMI
Yoshio TSUJITA / p223～223
Pharmacology The Effects of R-75,317 on Antiglomerular Basement Membrane Glomerulonephritis in Rats / Masaaki MIYAMOTO
Hiroyuki KOIKE
Toshio SADA
Yasuteru IIJIMA
Junichiro FUKUSHIGE
Norio NAKAMURA / p223～224
Pharmacology Research and Development of Pravastatin / Yoshio TSUJITA
Yukichi KISHIDA / p224～224
Pharmacology Characterization of CS-045, a New Oral Antidiabetic Agent II. Effects on Glycemic Control and Pancreatic Islet Structure at a Late Stage of the Diabetic Syndrome in C57BL/KsJ-db/db Mice / Toshihiko FUJIWARA
Pharmacology Pharmacology of HMG-CoA Reductase Inhibitors in Experimental Animals / Masao KURODA / p226～227
Pharmacology Research and Development of Pravastatin / Yukichi KISHIDA
Atsushi NAITO
Seigo IWADO
Akira TERAHARA
Yoshio TSUJITA / p227～227
Pharmacology Antihypertensive Effects of Temocapril Hydrochloride (CS-622), a Novel Angiotensin Converting Enzyme Inhibitor / Hiroshi NISHINO
Kiyoshi OIZUMI
Keiko IKEDA
Masaaki MIYAMOTO
Hiroyuki KOIKE / p228～228
Pharmacology Central and Peripheral Hemodynamic Effects of Temocapril Hydrochloride, a Novel Angiotensin Converting Enzyme Inhibitor, in SHR / Kiyoshi OIZUMI
Toshio SADA
Shigeki MIYAKE
Hiroyuki KOIKE / p228～229
Pharmacology General Pharmacological Studies on Temocapril Hydrochloride, a New Angiotensin Converting Enzyme Inhibitor / Hiroyuki KOIKE
Nobuyoshi IWATA
Takeshi OSHIMA
Shigeki MIYAKE
Fumitoshi ASAI
Yoshio IIZUKA
Hiroyoshi HORIKOSHI
Masaharu FUKAMI
Hiroshi TOKIWA
Katsuo KAMOSHITA / p229～229
Pharmocokinetics Carrier-mediated Uptake of Pravastatin by Rat Hepatocytes in Primary Culture / Toru KOMAI
Eiji SHIGEHARA
Taro TOKUI
Teiichiro KOGA
Michi ISHIGAMI
Chitose KUROIWA
Seikoh HORIUCHI / p229～230
Pharmocokinetics Determination of Enalapril and its Active Metabolite Enalaprilat in Plasma and Urine by Gas Chromatography/mass Spectrometry / Hiroaki SHIOYA
Masako SHIMOJO
Yukinori KAWAHARA / p230～230
Pharmocokinetics Nephroprotective Effect and Its Mechanism of Betamipron(1)Relationships of Renal Transport / Hideo NAGANUMA
Hiroshi TOKIWA
Yasukuni HIROUCHI
Yukinori KAWAHARA
Junichiro FUKUSHIGE
Masaharu FUKAMI
Koji HIROTA
Shigeki MURAMATSU
Hidekuni TAKAHAGI
Ken-ici INUI
Yusuke TANIGAWARA
Masato YASUHARA
Ryohei HORI
Shogo KAWAHARA / p231～231
Pharmocokinetics Nephroprotective Effect and Its Mechanism of Betamipron(2)Relationships of Renal Excretion / Hideo NAGANUMA
Yasukuni HIROUCHI
Yukinori KAWAHARA
Ken-ici INUI
Yusuke TANIGAWARA
Masato YASUHARA
Ryohei HORI
Shogo KUWAHARA / p231～232
Pharmocokinetics Microbiological Assay Method for the Determination of Panipenem Concentrations in Body Fluids / Masafumi HISAOKA
Masato ICHIKAWA
Toshio TERAO / p232～233
Pharmocokinetics High-performance Liquid Chromatography (HPLC) for the Determination of Panipenem/betamipron Concentrations in Body Fluid / Masafumi HISAOKA
Hideo NAGANUMA
Hidekuni TAKAHAGI
Yukinori KAWAHARA
Yasushi YAMAZAKI / p233～234
Pharmocokinetics Metabolic Studies on Panipenem/betamipron Distribution, Metabolism and Excretion of Panipenem/betamipron in Rats and Dogs / Hidekuni TAKAHAGI
Yoko MATSUSHITA
Takashi HIROTA
Akemi SHIGETA
Shigeki MURAMATSU
Eiichi NAKAJIMA
Yukinori KAWAHARA / p234～234
Pharmocokinetics In vitro Dehydropeptidase-I Activity and Its Hydrolytic Activity of Panipenem in Several Tissues in Animal Species and Their Influence on the Disposition of Panipenem in vivo / Hidekuni TAKAHAGI
Takashi HIROTA
Yoko MATSUSHITA
Shigeki MURAMATSU
Minoru TANAKA
Eiichi MATSUO / p234～235
Pharmocokinetics Phase I Study of Panipenem/betamipron I Single Dose Study / Mitsuyoshi NAKASHIMA
Toshihiko UEMATSU
Mitsutaka KANAMARU
Masazo TAJIMA
Hideo NAGANUMA
Masafumi HISAOKA
Yukinori KAWAHARA
Hidekuni TAKAHAGI / p235～235
Pharmocokinetics Phase I study of Panipenem/betamipron II Multiple Dose Study / Mitsuyoshi NAKASHIMA
Toshihiko UEMATSU
Mitsutaka KANAMARU
Masazo TAJIMA
Hideo NAGANUMA
Masato ICHIKAWA
Masafumi HISAOKA
Yukinori KAWAHARA / p236～236
Pharmocokinetics Phase I Study of Panipenem/betamipron III Dissolved in Solita T3® / Mitsuyoshi NAKASHIMA
Toshihiko UEMATSU
Satoru NAGASHIMA
Hiroshi INABA
Kazuhiro KOSUGE
Keiko HIRANO
Masazo TAJIMA
Atsushi KURIHARA
Masato ICHIKAWA
Toshio TERAO
Masafumi HISAOKA / p236～237
Pharmocokinetics Application of Antibody-mediated Extraction for the Stereoselective Determination of the Active Metabolite of Loxoprofen in Human and Rat Plasma / Wataru TAKASAKI
Yorihisa TANAKA / p237～237
Pharmocokinetics Neurotoxicity of Panipenem/betamipron, a New Carbapenem, in Rabbits: Correlation to Concentration in Central Nervous System / Atsushi KURIHARA
Masafumi HISAOKA
Naoji MIKUNI
Katsuo KAMOSHITA / p238～238
Pharmocokinetics Intrathecal Distribution of ACNU by Various Modes of its Administration Analyzed by HPLC and Autoradiography / Tomokatsu HORI
Jun HIRAO
Hisayo OKAMOTO
Makoto NISHIYAMA
Satoshi TANAKA
Kiyoaki MURAOKA
Fumie TABUCHI
Tohru TATSUHARA
Eiichi NAKAJIMA / p238～239
Pharmocokinetics Cell Membrane Transport Mechanism and Liver Selective Transport of HMG-CoA Reductase Inhibitors / Toru KOMAI / p239～240
Pharmocokinetics Application of Imaging Plate Method in Drug Metabolism Studies / Eiichi NAKAJIMA / p241～241
Pharmocokinetics Metabolism of Pravastatin Sodium in Isolated Rat Hepatocytes. I. Glutathione Conjugate Formation Reaction / Shigeki MURAMATSU
Kimitoshi MIYAGUCHI
Haruo IWABUCHI
Yoko MATSUSHITA
Takemichi NAKAMURA
Takeshi KINOSHITA
Minoru TANAKA
Hidekuni TAKAHAGI / p241～242
Pharmocokinetics Metabolism of RS-0481, a New Host Mediated Antitumor Activator(1)Identification of Metabolites in Rat and Dog / Haruo IWABUCHI
Mikako ENOMOTO-IDA
Toshihiko IKEDA
Harumitsu KUWANO
Kan-ichi NAKAMURA
Junichi SAKAI
Mitsuo NAGANO / p242～242
Pharmocokinetics Drug Metabolism Study in Humans(2)in vitro Study of Drug Metaborism with Human Hepatocytes / Minoru TANAKA / p243～243
Pharmaceutics Mechanism of Caking of Granules Containing Oily Materials / Naoki WAKIYAMA
Akira KUSAI
Kenji NISHIMURA / p243～243
Pharmaceutics A New Concept for Interpretation of First-order Release from Albumin Microspheres / Junichi OKADA
Satsuki ASANO
Tamotsu KONDO / p243～244
Pharmaceutics An Analysis of First-order Release Kinetics from Albumin Microspheres / Junichi OKADA
Yumi MASUYAMA
Tamotsu KONDO / p244～245
Veterinary Synthesis of 5-Keto-5-oxime Derivatives of Milbemycins and their Activities against Microfilariae / Yoshihisa TSUKAMOTO
Kazuo SATO
Shigeru MIO
Soji SUGAI
Toshiaki YANAI
Noritoshi KITANO
Shigeki MURAMATSU
Yasuo NAKADA
Junya IDE / p245～245
Veterinary Ophthalmological Study on Buphthalmia in Japanese White Rabbits--Intraocular Pressure Variation and Aqueous Humor Dynamics / Tsunemichi HOSOKAWA
Yukio SASAKI / p245～246
Veterinary Immunogenicity Studies in Experimental Animals Immunized with a Low-Molecular Antigen Alone and the Antigen Plus Adjuvants / Kenkichi SHINKAI
Nobuhiro ISHIKAWA
Tsutomu KIMURA / p246～247
Veterinary Phospholipase C-δ gene of the Spontaneously Hypertensive Rat Harbors Point Mutations Causing Amino Acid Substitutions in a Catalytic Domain / Hitoshi YAGISAWA
Hisao TANASE
Hiroshi NOJIMA / p247～247
Veterinary Apparatuses for Obtaining Continuous 24-hour Records of Water Intake and Urinary Output in Dogs / Chitoshi TARUMI
Tatsuhiko TAKAHASHI
Hiroshi MASUDA / p248～248
Environmental Health Biological Treatment of Chlorhexidine Digluconate-containing Waste Water. I. Effect of Chlorhexidine Digluconate on Activated Sludge Treatment / Nobunari SUGIO
Syunshi KOJIMA / p248～249
Agrochemicals Metabolic Fates of Milbemycin A₃ and A₄ in Rats / Shingo SADAKANE
Keiji TANAKA
Etsuko MURAOKA
Mitsuru ANDO / p249～249
Agrochemicals Comparative Metabolism of Milbemycin A₃ and A₄ in Rat Liver Microsomes / Shingo SADAKANE
Keiji TANAKA
Kazuo SATO
Mitsuru ANDO / p249～250
Agrochemicals Laboratory Evaluation of the Protective Efficacy of Ethofenprox against Termites / Kiyoshi KONISHI
Kenya OKUMURA
Toshiyasu SHIZAWA / p250～250
Agrochemicals Differential Susceptibility of Phytophthora infestans Mating Types A1 and A2 to Mancozeb and Cupric Sulfate / Shigehiro KATO / p250～251
Agrochemicals Pharmacokinetic Studies of the Recombinant Juvenile Hormone Esterase in Manduca sexta / Reiji ICHINOSE
Shizuo G. KAMITA
Susumu MAEDA
Bruce D. HAMMOCK / p251～251
Agrochemicals Effects of Recombinant Juvenile Hormone Esterase on Aedes Aegypti / Lawrence G. HARSHMAN
