Generation of the Mitochondrial DNA Knockout Mice

[目次]

  • TABLE OF CONTENTS / p1
  • Abstract / p1
  • General Introduction / p5
  • Figure I / p10
  • Abbreviations / p12
  • Section I / p13
  • Mutant mtDNA at 12S rRNA 1555 A to G and hypersusceptibility of mitochondrial translation to streptomycin are co-transferred to ρ⁰ HeLa cells / p13
  • Introduction / p14
  • Materials and Methods / p17
  • Results / p19
  • Discussion / p21
  • Table / p23
  • Figures and Figure legends / p24
  • Section II / p30
  • Isolation of mtDNA-less mouse cell lines and their application for trapping mouse synaptosomal mtDNA with deletion mutations / p30
  • Introduction / p31
  • Materials and Methods / p34
  • Results / p37
  • Discussion / p42
  • Table / p46
  • Figures and Figure legends / p47
  • Section III / p57
  • Isolation and characterization of mitochondrial DNA-less lines from various mammalian cell lines by application of an anticancer drug, Ditercalinium / p57
  • Introduction / p58
  • Materials and Methods / p60
  • Results / p63
  • Discussion / p65
  • Table / p67
  • Figures and Figure legends / p68
  • Section IV / p72
  • Generation of mitochondrial DNA knockout mice by introduction of mouse mitochondrial DNA with a deletion mutation into zygotes / p72
  • Introduction / p73
  • Materials and Methods / p75
  • Results / p81
  • Discussion / p85
  • Table / p88
  • Figures and Figure legends / p89
  • General Discussion / p113
  • Conclusion / p119
  • References / p120
  • Acknowledgments / p134

「国立国会図書館デジタルコレクション」より

この本の情報

書名 Generation of the Mitochondrial DNA Knockout Mice
著作者等 Kimiko Inoue
井上 貴美子
書名別名 ミトコンドリア遺伝子疾患モデルマウスの作製
刊行年月 2000
言語 英語
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