Stereoselective synthesis of 1α,25-dihydroxyvitamin D[3]

[目次]

  • Contents
  • Chapter1."General Introduction." / p1
  • 1-1.Introduction. / p1
  • 1-2.Metabolism of Vitamin D₃ and Its Biological Activities. / p1
  • 1-3.Recent Advances for Synthesis of Vitamin D₃ Metabolites. / p5
  • Chapter2."Stereoselective Synthesis of Cyclopentanones by Reductive Cleavage of Norbornan-6-one-2-Carboxylates and Its Application to Synthesis of 1α,25-Dihydroxyvitamin D₃ CD-ring." / p9
  • 2-1.Introduction. / p9
  • 2-2.Synthesis of 2,3-Disubstituted Cyclopentanones by Reductive Cleavage of Norbonan-6-one-2-carboxylates. / p10
  • 2-3.Synthesis of 25-Hydroxyvitamin D₃ CD-Ring from the Cyclopentanone via Robinson Annulation and Transposition of the α,β-Unsaturated Ketone. / p12
  • 2-4.Conclusion. / p17
  • 2-5.Experimental Section. / p18
  • Chapter3."Synthetic Approach to 1α,25-Dihydroxyvitamin D₃ CD-Ring by Photocycloaddition." / p32
  • 3-1.Introduction. / p32
  • 3-2.Synthetic Strategy. / p32
  • 3-3.Synthesis of γ-Methyl-α,β-Unsaturated-δ--Valerolactone 57. / p35
  • 3-4.Examination of Photocycloaddition Reaction of γ-Methyl-α,β-Unsaturated-δ-Valerolactone 57 with 3-Methyl-2-cyclohexenone. / p36
  • 3-5.Conclusion. / p40
  • 3-6.Experimental Section. / p41
  • Chapter4."An Efficient Asymmetric Synthesis of 1α,25-Dihydroxyvitamin D₃ A-Ring Synthon." / p44
  • 4-1.Introduction. / p44
  • 4-2.Palladium-Catalyzed Intramolecular Cyclization of 8-Bromo-2,8-nonadienoates. / p45
  • 4-3.Asymmetric Synthesis of the A-Ring Synthon and Its Application to Synthesis of 1α,25-Dihydroxyvitamin D₃. / p49
  • 4-4.Conclusion. / p51
  • 4-5.Experimental Section. / p52
  • Chapter5."Palladium-Catalyzed Dehydrogenative Carbonylation of 1-Alkynes and Its Application to Synthesis of 1α,25-Dihydroxyvitamin D₃ A-Ring Synthon." / p66
  • 5-1.Introduction. / p66
  • 5-2.Synthesis of 7-Bromo-7-octen-1-yne and Examination of Tandem Cyclization Reaction. / p68
  • 5-3.Palladium-Catalyzed Dehydrogenative Carbonylation of Phenylacetylene. / p71
  • 5-4.Conclusion. / p73
  • 5-5.Experimental Section. / p74
  • Chapter6."General Summary." / p77
  • References and Notes. / p81

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書名 Stereoselective synthesis of 1α,25-dihydroxyvitamin D[3]
著作者等 長澤 和夫
書名別名 1α,25-ジヒドロキシビタミンD[3]の立体選択合成
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